期刊文献+

低分子肝素防治脓毒症机制的研究进展 被引量:3

Study on prevention and cure of sepsis by low molecular weight heparin
下载PDF
导出
摘要 目的脓毒症的研究在过去四十年里取得了一定的进展,自人类重组活化蛋白C的出现以来,我们已认识到凝血系统紊乱在脓毒症中的重要地位,而低分子肝素作为在临床上广泛使用的抗凝药物,现已发现其在脓毒症的各个环节都有其阻断作用,本文就其机制做一综述。 There is some progress on the study of sepsis in past 40 years. When rhAPC comes out, we have known the importance of blood coagulation function imbalance caused by sepsis. Low molecular weight heparin has been widely used in hospital as anticoagulant. We discover it can block sepsis in many experiments, in this article, we summarize its mechanism.
作者 卢骁 赵良
出处 《中国急救医学》 CAS CSCD 北大核心 2008年第11期1033-1036,共4页 Chinese Journal of Critical Care Medicine
基金 解放军第二军医大学附属长征医院"三重三优"学科人才建设计划项目(No.060106)
关键词 脓毒症 低分子肝素 Sepsis Low molecular weight heparin
  • 相关文献

参考文献28

  • 1Wright SD, Ramos RA, Tobias PS, et al. CD14, a receptor for complexes of lipopolysaccharide ( LPS ) and LIPS binding protein [ J ]. Science, 1990,249 (4975) : 1431 - 1433.
  • 2Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene[J]. Science, 1998,282(5396) :2085-2088.
  • 3Medzhitov R, Preston- Hurlburt P, Janeway CA Jr, et al. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity [ J]. Nature, 1997,388 (6640) :394 - 397.
  • 4Beutler B. Tlr4 : central component of the sole mammalian LPS sensor [J]. Curr Opin Immunol, 2000,12( 1 ) :20-26.
  • 5Espevik T, Otterlei M, Skjak - Braek G, et al. The involvement of CD14 in stimulation of cytokine production by uronic acid polymers [J]. Eur J Immunol,1993,23(1) :255 -261.
  • 6McBride WT, Armstrong MA, and McMurray TJ. An investigation of the effects of heparin, low molecular weight heparin, protamine, and fentanyl on the balance of pro - and anti - inflammatory cytokines in in - vitro monocyte cultures [ J ]. Anaesthesia, 1996,51 ( 7 ) : 634 - 640.
  • 7Heinzelmann M, Miller M, Platz A, et al. Heparin and enoxaparin enhance endotoxin - induced tumor necrosis factor - alpha production in human monocytes [ J ]. Ann Surg, 1999, 229 (4) :542 -550.
  • 8Heinzelmann M, Bosshart H. Heparin binds to lipopolysaccharide (LPS) - binding protein, facilitates the transfer of LPS to CD14, and enhances LPS - induced activation of peripheral blood monocytes [ J ]. Immunol,2005,174 (4) :2280 - 2287.
  • 9Wan MX, Zhang XW, Torkvist L, et al. Low molecular weight heparin inhibits tumor necrosis factor alpha - induced leukocyte rolling [J]. Inflammres, 2001,50(12) :581 -584.
  • 10Manduteanu I, Voinea M, Capraru M, et al. A novel attribute of enoxaparin : inhibition of monocyte adhesion to endothelial cells by a mechanism involving cell adhesion molecules [ J ] . Pharmacology, 2002,65( 1 ) :32 -37.

二级参考文献6

  • 1Kratz G,Arnander C,Swedenborg J,et al.Heparinchitosan complexes stimulate wound healing in human skin.Scand J Plast Reconstr Surg Hand Surg,1997,31:119-123.
  • 2Wang P,Singh G,Rana MW,et al.Preheparinization improves organ function after hemorrhage and rususcitation.Am J physiol,1990,259:645-650.
  • 3Rana MW,Sing G,Wang P,et al.Protective effects of preheparinization on the microvasculature during and after hemorrhagic shock.J Trauma,1992,32:420-426.
  • 4Sirvent Lz,Hansbroug JF,Greenleaf GE,et al.Reduction of bacterial translocatoin and intestinal structural alterations by heparin in a murine burn injury modelk.J Trauma,1994,36:1-6.
  • 5Zellweger R,Ayala A,Zhu XL,et al.A novel nonanticoagulant haperin improves splenocyte and peritoneal macrophage immune function after trauma hemorrhage and resusciation.J Surg Res,1995,59:211-218.
  • 6刘禹赓,李春盛.全身炎症反应综合征患者凝血系统功能紊乱的研究[J].中华内科杂志,2004,43(2):94-97. 被引量:33

共引文献13

同被引文献5

引证文献3

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部