2型糖尿病家系青少年一级亲属心血管危险因素研究

Study on risk factors for cardiovascular disease in adolescents with a family history of type 2 diabetes

目的探讨2型糖尿病(T2DM)家族史对青少年心血管危险因素的影响。方法秦皇岛地区12～18岁青少年4023人横断面调查。根据父母有无糖尿病分为糖尿病家族史阳性组(FH+)和阴性组(FH-)。测量腰围(WC)、血压、FPG、血脂,计算BMI。结果(1)FH+组腰围、FPG、TC和LDL-C均高于FH-组(P<0.05),超重/肥胖、高SBP、高FPG检出率高于FH-组(P<0.05)。(2)校正年龄、性别后FH+组SBP、FPG升高、超重/肥胖的危险性分别是FH-组的1.54、2.06、1.33倍,95%CI分别是(1.10～2.16)、(1.46～2.89)、(1.12～1.59),具有2项以上心血管危险因素的危险性是FH-组的1.72倍。结论T2DM患者的青少年一级亲属已存在心血管危险因素增加和聚集。应重视对这一人群进行早期筛查和干预,以减少心血管病的发生。

Objective To explore the risk factors for cardiovascular disease in adolescents with a family history of type 2 Diabletes. Methods A cross sectional study was conducted in 4023 adolescents aged 12 18 years. They were divided into two groups with （FH^＋ ） and without （FH^-） family history of diabetes and measurements included BMI, waist circumference, blood pressure and fasting plasma glucose （FPG）, total cholesterol （TC）, triglyceride（TG） and high-density lipoprotein cholesterol （HDL-C）. Results When compared with FH^- group,FH^＋ group had significantly high levels of waist circumference, FPG,TC and LDL-C（all P〈0.05）. The prevalence rates of overweight,obesity and high SBP, FPG were higher in FH^＋ group than in FH^- group. After adjusting the gender and age, the odds ratios （95%CI） of FH^＋ adolescents group for high SBP, high FPG, overweight or obesity were 1.54 （1.10-2.16）, 2.06 （1.46- 2.98） and 1.33 （1.12- 1.59） respectively. Odds rations of the risk for two cardiovascular disease factors was 1.72 times in FH^＋ group versus in FH^- group. Conclusions In adolescents with a family history of type 2 diabetes, the clustering of risk factors for cardiovascular disease is increased. Taking early inspection of, and following up this group will effectively decrease the cardiovascular disease.