基于以药测证的热病证候模型评价方法研究

Research on evaluation methods of the fever syndrome model based on evaluating syndrome using drug intervention

目的:建立一套完善的中医证候动物模型的评价方法。方法:以2,4-二硝基苯酚诱导的热病证候模型为切入点,利用寒性药物与温性药物对比干预的实验研究,探讨动物模型的评价方法。结果:寒性药物与温性药物干预的对比研究结果表明,2,4-二硝基苯酚诱导的动物模型符合中医临床的热病证候表征。结论:2,4-二硝基苯酚所复制的动物模型为热病证候模型,而非炎症发热模型。

Objective: To establish a set of consummate evaluation methods of animal models which are with syndromes of Traditional Chinese Medicine.Methods: By means of 2,4-dinitrophenol induced fever syndrome model for the entry point,making use of drugs which are respectively cold property and warm property to interfere in the model,to approach the evaluation methods of animal models.Results: Through the comparative study between cold-drug and warm-drug to interfere in the fever syndrome model,the results showed that 2,4-dinitrophenol induced animal models consisted with clinical fever syndrome of traditional Chinese medicine.Conclusion: the animal model induced by 2,4-dinitrophenol is the fever syndrome model,rather than fever model mediated by inflammation.