摘要
本研究用甘露醇、糊精及适宜的矫味剂、稳定剂等为辅料，制成维生素C含片。考察不同湿润剂或粘合剂（Ⅰ：50％乙醇；Ⅱ：5．6％Ⅱ号肠溶性丙烯酸树脂醇溶液；Ⅲ：重量各半的羟丙基甲基纤维素的2％水溶液和16％的淀粉浆）对制剂稳定性的影响。结果显示，在高温（80℃、60℃）、高湿（RH925％、RH75％）条件下，使用粘合剂Ⅲ，可以增加制剂的稳定性。
Vitamin C buccal tablets were prepared using various excipients, including mannitol,dextrin,appropriate correctives and stabilizer. Effects of different wetting agents or adhesives on thestability of vitamin C tablets were investigated with accelerator test. The results showed that theadhesive Ⅲ consisting of 2% hydroxypropyl methylcellulose and 16% starch mucilage exertedsignificant stabilizing effects on the preparation of vitamin C,under the condition of high temperature(80℃, 60℃) and relatively high humidities(RH 92. 5 %,RH 75 % ).
