从甲基苯丙胺的杂质分布图推断合成信息

Determination of the synthetic route based on impurity profiling of methamphetamine

目的通过杂质分布图,分析甲基苯丙胺(MA,俗称"冰毒")的合成路线,为公安机关打击毒品犯罪提供技术支持。方法将甲基苯丙胺样品溶于磷酸盐缓冲液,用乙酸乙酯萃取(含有4个内标,C10、C15、C20和C28),对萃取液进行GC-MS分析。结果对北京市公安局2006～2007年间缴获的8批样品进行分析,结果表明其中6批是以麻黄碱或伪麻黄碱为原料合成的,采用技术路线为碘酸/红磷方法。结论麻黄碱或伪麻黄碱是目前合成甲基苯丙胺的主要原料。

Objective Impurity profiling of seized methamphetamine may play an important role in the determination of the synthetic method employed and the criminal investigations of drug traffic routes. Methods A sample of methamphetamine was dissolved in buffer solution. Impurities were extracted with ethyl acetate containing four internal standards （n-decane, n-pentadecane, n-eicosane and n-octacosane） and analyzed by GC-MS. Results These data are suggestive of ephedrine/pseudoephedrine as the main precursor of the methamphetamine samples seized during 2006-2007. Six samples of selected eight samples were synthesized via the more specific ephedrine/hydriodic acid/red phosphorus method. Conclusion Ephedrine/pseudoephedrine is common material used to synthesize methamphetamine.