哺乳动物卵母细胞凋亡的研究现状及新进展

Research actuality and new advances of Oocyte Apoptosis in Mammals

细胞凋亡又称程序性细胞死亡,是指机体为维持体内环境的稳定,由基因控制的细胞自主的有序性死亡。对于雌性生殖系而言,细胞凋亡是维持其正常功能的一个重要组成要术。就哺乳动物来说,超过99.9%的雌性生殖细胞会在发育的不同时期发生凋亡。本文主要综述了细胞凋亡的新概念、卵子发生过程中的细胞凋亡现象,同时还对当今卵母细胞凋亡研究的现状及新进展做出了总结。

Apoptosis is a fundamental life phenomenon during the development of various organisms. In addition to the somatic cell apoptosis,germ cell apoptosis also occurs in many kinds of animals. Apoptosis is essential to the female germ line development. In mammals , up to 99.9% female germ cells are lost through apoptosis during oogenesis. The present paper reviews the new concept of programmed cell death and the phenomenon of oocyte apoptosis in Egg-production process. The research actuality and new advances of oocyte apoptosis in mammals is also discussed.