不同疗程干扰素治疗慢性乙型肝炎随访3年的临床研究

The clinical research of different course of treatment with interferon-α in patients with chronic hepatitis B in three year follow-up

目的比较长疗程和短疗程干扰素治疗慢性乙型肝炎的治疗效果。方法在HBsAg和HBeAg、HBV DNA均为阳性的慢性乙型肝炎病人235例中,应用干扰素-α2b5MU肌肉注射,隔日1次,一组(153例)患者以12个月为一个疗程,另一组(82例)患者以6个月为一个疗程,两组病人于治疗结束后均随访36个月。结果两组患者HBsAg阴转率和近期应答率无明显差别(P>0.05);长疗程组的ALT复常率、HBeAg阴转率、HBeAb阳转率和HBV DNA阴转率均高于短疗程组(P<0.05);短疗程组的复发率高于长疗程组(P<0.05),其持续应答率低于长疗程组(P<0.01)。结论长疗程干扰素治疗慢性乙型肝炎的疗效优于短疗程治疗。

Objective To investigate the therapeutic efficacy of interferon therapy in patients with chronic hepatitis B. Methods This study involved 235 patients with HBsAg,HBeAg and HBV DNA positive. All patients received IFN- α2b at dose of 5MU every other day for 12 months（153 cases）or for 6 months（82 cases）. All patients were followed-up for 36 months. Results There were no differences in HBsAg loss and early response rate in the two groups at the end of the therapy. There were significantly differences as respect to the ALT recovery,the negative rate of HBeAg,the positive rate of HBeAb,and the loss of HBV DNA between the two groups（P〈0.05）. The relapse rate in short-term course of treatment was higher,and the sustained response was lower than that in the long-term course of treatment（P〈0.05）. Conclusion The therapeutic efficacy of long-term course of treatment with interferon in patients with chronic hepatitis B is better.