林可霉素、克林霉素磷酸酯注射液分别与8种大输液配伍的稳定性

Study on the compatible stabilities of lincomycin injection and clindamycin phosphate injection with eight different kinds of infusion

目的研究室温6h内林可霉素、克林霉素磷酸酯注射液分别与乳酸钠林格液、复方乳酸钠葡萄糖液、复方乳酸钠山梨醇液、复方电解质葡萄糖R2A、M3A、M3B、MG3、R4A注射液配伍后的稳定性。方法采用HPLC法分别测定配伍后林可霉素、克林霉素磷酸酯的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果在室温下配伍溶液6h内澄清,pH值、不溶性微粒和含量均无明显变化。结论林可霉素、克林霉素磷酸酯注射液分别与乳酸钠林格液、复方乳酸钠葡萄糖液、复方乳酸钠山梨醇液、复方电解质葡萄糖R2A、M3A、M3B、MG3、R4A注射液配伍后6h内稳定,可安全应用于临床。

AIM To study the stabilities of lincomycin injection and clindamycin phosphate injection respectively with sodium lactate ringer＇ s injection, compound sodium lactate and glucose injection, compound sodium lactate and sorbitol injection, electrolytes and glucose composition R2A, M3A, M3B, MG3, R4A injection in room temperature in 6 h. METHODS RP-HPLC was used to observe the content changes of lincomycin, clindamycin phosphate. The pH , quantity of non-soluble particulate and appearance of mixtures were also observed. RESULTS The mixtures were all clear and produced neither gas nor sediment. The pH , quantity of non-soluble particulate and contents hardly changed in 6 h in room temperature. CONCLUSION The mixtures of lincomycin injection and chndamycin phosphate injection with eight kinds of infusion are stable in 6 h, and can be used safely in the clinic.