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Axin与MMP-14在食管鳞癌中的表达及与浸润转移的关系 被引量：5

Association of Axin and MMP-14 expression with infiltration and metastasis of esophageal squamous cell carcinoma
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摘要 目的:探讨Axin蛋白和MMP-14蛋白在食管鳞癌中的表达及与浸润转移的关系以及两者表达的相关性。方法:采用免疫组织化学(SP)法对72例食管鳞癌标本中Axin蛋白和MMP-14蛋白的表达进行了检测。结果:食管鳞癌中Axin蛋白的阳性表达率仅为38.9%,在有纤维膜浸润食管癌中的表达明显低于无纤维膜浸润者(P<0.05);有淋巴结转移组的表达明显低于无淋巴结转移组(P<0.05)。食管鳞癌中MMP-14蛋白的阳性表达率为62.5%,在高分化的食管鳞癌组织中的表达明显低于中低分化者(P<0.05);在有纤维膜浸润食管鳞癌中的表达明显高于无纤维膜浸润者(P<0.05);有淋巴结转移组的表达明显高于无淋巴结转移组(P<0.01)。食管鳞癌Axin和MMP-14的表达具有相关性(P<0.05)。结论:Axin蛋白的低表达和MMP-14蛋白的高表达与食管鳞癌的浸润及转移均有关,二者表达呈负相关,有望成为判断食管鳞癌的转移潜能及预后的有效指标。
作者 张欣 张会超 郭建文 刘江惠 左连富
机构地区 河北医科大学第四医院肿瘤研究所流式细胞室
出处 《第二军医大学学报》 CAS CSCD 北大核心 2008年第11期1409-1411,共3页 Academic Journal of Second Military Medical University
基金 河北省普通高等学校强势特色学科肿瘤学建设经费(冀教高[2005]52号)~~
关键词 AXIN MMP-14 食管肿瘤 免疫组织化学 WNT通路
分类号 R735.1 [医药卫生—肿瘤]
  • 相关文献

参考文献11

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二级参考文献33

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共引文献12

同被引文献53

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引证文献5

二级引证文献21

第二军医大学学报
2008年 第11期

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