眼科药物实验研究应注意的一些问题

Experimental tests of ophthalmic drags and related issues

新药或已知药物在眼病的应用研究是眼科研究的一个主要课题。但近年发表的眼科药物实验研究文献中，反映出部分实验研究存在缺乏系统、规划和规范；没有细胞学筛选实验，直接进行动物实验；缺乏与已知药物对照等问题。为提高相关研究的质量，研究者应该熟悉新药研究的规范步骤、应用体外细胞学模型以及活体动物模型进行荮物筛选和效果评估研究的基本规则。

Study of new or previously known drugs for new applications in the treatments of eye diseases has been one of the major subjects in the ophthalmic field. However, we had found several caveats in the recently published papers on experimental ophthalmic drug studies, such as new drug trials lack of systemic designing, experimental studies without following the standard guidelines, in-vivo animal tests bypassed the necessary in-vitro cell screenings, and studies lack known drug controls, etc. In order to improve the quality of such kind of studies, researchers should be familiar with the standard procedures of new drug testing, and with the basic rules for drug screenings and efficacy assessments by in vitro cell culture systems and in-vivo animal models.