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Cripto-1蛋白在急性白血病中的表达 被引量：1

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摘要 Cripto-1是表皮生长因子-Cripto-FRL-Criptic（EGF-CFC）家族成员之一，其基因定位在人染色体3P21．3。已经发现Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、胰腺癌等中高表达，它可以激活P13K／Akt／GSK-3βc-Src和ras／raf／MAPK信号通路，介导细胞增殖和抑制细胞凋亡。目前有关Cripto-1在急性白血病中的表达情况及其与P13K／Akt信号通路之间的关系尚未见报道，我们观察了Cripto-1和p-Akt在白血病中的表达，并分析其与临床疗效之间的关系，旨在探讨Cripto-1在白血病发生、发展及其与临床耐药的关系。
作者 包丰昌 孙慧 张秋堂 马杰
机构地区 郑州大学第一附属医院血液科
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第11期776-777,共2页 Chinese Journal of Hematology
关键词 急性白血病 P13K/AKT MAPK信号通路 AKT信号通路 蛋白 表皮生长因子 GSK-3Β 临床疗效
分类号 R686 [医药卫生—骨科学]
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参考文献14

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同被引文献23

  • 1窦爱霞,贾培敏,朱琦,赵倩,王振义,童建华.腺苷酸环化酶的活化影响NB4细胞对全反式维甲酸的敏感性[J].中华血液学杂志,2004,25(11):675-678. 被引量：5
  • 2付劲蓉,刘文励,周剑锋,孙汉英,郑邈,黄梅,李春蕊,冉丹,罗莉.Mcl-1基因在HL-60细胞对全反式维甲酸耐药机制中的作用[J].中华血液学杂志,2005,26(6):352-354. 被引量：7
  • 3Awwad RT, Do K, Stevenson H, et al. Overexpression of BP1, a homeobox gene ,is associated with resistance to all-trans retinoie acid in acute promyelocytic leukemia cells [J]. Ann Hematol, 2008,87 ( 3 ) : 195 - 203.
  • 4Lulli V, Romania P, Riccioni R, et al. Transcriptional silencing of ETS1 oncogenc contributes to human granulocytic differentiation [ J ]. Haematologica,2010,95 (10) : 1633 - 1641.
  • 5Heuser M, Argiropoulos B, Kuchenbauer F,et al. MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML[J]. Blood,2007,110(5) :1639 - 1647.
  • 6Ritter M, Kattmann D, Teichler S, et al. Inhibition of retinoic acid receptor signaling by Ski in acute myeloid leukemia[J]. Leukemia,2006 ,20 (3) :437 -443.
  • 7Bianco C, Strizzi L, Rehman A, et al. A Nodal - and ALK4 - independent signaling pathway activated by Cripto - 1 through Glypiean - 1 and c - Src[J]. Cancer Res,2003,63 (6) :1192 - 1197.
  • 8Meyer PN, Roychowdhury S, Kini AR, et al. HSP90 inhibitor 17AAG causes apoptosis in ATRA - resistant acute promyelocytic leukemia cells [ J ]. Leuk Res,2008,32 ( 1 ) :143 - 149.
  • 9Miranda MB,Redner RL,Johnson DE. Inhibition of Src family kinases enhances retinoic acid induced gene expression and myeloid differentiation[J]. Mol Cancer Ther,2007,6( 12 Pt1 ) :3081 -3090.
  • 10McNamara S, Wang H, Hanna N, et al. Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function:A novel mechanism of retinoic acid resistance [ J ]. Mol Cell Biol, 2008,28 ( 6 ) : 2066 - 2077.

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中华血液学杂志
2008年 第11期

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