脂溢性角化病128例临床病理分析

Clinicopathological Analysis of 128 Cases with Seborrheic Keratosis

目的探讨脂溢性角化病的临床及组织病理学特点。方法对近10年来128例脂溢性角化病患者的临床及病理资料进行回顾性分析。结果六种类型脂溢性角化病的组织象均可见到,并以棘层肥厚型和角化过度型为主。51岁以上发病者占71.9%,头、面、颈等暴光部位发病者占53.9%,临床和病理诊断符合89例,临床误诊率30.47%。结论发病年龄虽有提前,但年龄的增加与脂溢性角化病的发病率仍成正比;暴露区域比非暴露区域更易患病,过度日光照射可能是其重要诱因;临床常易误诊,需与相关皮肤病鉴别。

Objective To learn the clinicopathologic features of seborrheic keratosis. Methods The clinical and pathological data of 128 cases of were analyzed retrospectively. Results among the 128 patients, 71.9% elder than 51-years-old, the lesions of 53.9% of patients located in the exposure sites, such as face and neck. For pathologic feature, six patterns were learned, the most frequent types were hyperkeratosis and acanthosis. The clinical diagnosis consisted with pathologic diagnosis in 89 cases. Clinical misdiagnosis rate was 30.47%. Conclusion Although early onset age, but age and the incidence rate is still a positive correlation; the lesions in exposed regions are more than that on non-exposed regions. Over-exposure to sunlight may be an important incidence factor. Seborrheic keratosis was easily misdiagnosed, and related skin diseases were to be identified.