摘要
肌肉(骨骼肌)组织对脂肪酸的利用水平是影响机体能量稳态的关键因素.肌肉摄取的长链脂肪酸(long-chainfatty acids,LCFAs)主要依赖细胞膜载体蛋白协助的跨膜转运过程.近年来,一系列与脂肪酸转运相关的膜蛋白被相继克隆鉴定,其中在肌肉中大量表达的有脂肪酸转运蛋白-1(fatty acid transport protein-1,FATP-1)、膜脂肪酸结合蛋白(plasma membrane fatty acid binding protein,FABPpm)、脂肪酸转位酶(fatty acidtranslocase,FAT/CD36)和小窝蛋白-1(caveolin-1).研究上述肌肉脂肪酸转运膜蛋白的结构功能、调控机制及相互关系,可能为肥胖等脂类代谢紊乱疾病的诊治提供新的手段.
The utilization of fatty acids in skeletal muscle plays an important role in the energy homeostasis of human bodies. The uptake of long-chain fatty acids in skeletal muscle mainly depends on the transmembrane- exchanges mediated by membrane transporters. In recently years, a series of membrane fatty acid transport proteins have been cloned and characterized. The fatty acid transport protein-1 （ FATP-1 ）, plasma membrane fatty acid binding protein（FABPpm）, fatty acid translocase （FAT/CD36） and caveolin-1 were found to be widely expressed in skeletal muscles. Investigating the structure, function, regulation and the interactions of these transporters may provide us with a new way of diagnosing and treating lipid metabolism diseases or disorders, such as obesity.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2008年第11期992-1000,共9页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学青年基金资助项目(No.30500367)
广东省自然科学基金资助项目(No.06025789)
广东省自然科学基金研究团队资助项目(No.04205804)~~
关键词
肌肉
脂肪酸跨膜转运
脂肪酸转运蛋白-1
膜脂肪酸结合蛋白
脂肪酸转位酶
小窝蛋白-1
muscle
fatty acid transmembrane-movement
fatty acid transport protein-1 （ FATP-1 ）
plasma membrane fatty acid binding protein（FABPpm）
fatty acid translocase （FAT/CD36）
caveolin-1
