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大电导钙激活钾通道与动脉粥样硬化 被引量：1

BKCa and atherogenesis
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摘要 动脉粥样硬化(AS)形成是一个复杂炎症反应的过程。多种致AS的危险因素,尤其是氧化型低密度脂蛋白存在,导致内皮细胞、单核巨噬细胞、血管平滑肌细胞及血小板等的大电导钙激活钾通道(BKCa)激活,后者促使细胞功能障碍,进而促进AS的形成。本文简要综述BKCa参与AS形成的研究进展。 Atherosclerosis is a kind of complex progressive inflammation. Exposure to atherogenic risk factors, particularly OxLDL, induces the activity of BKca in endothelial cell, monocyte/macrophage （MΦ）, vascular smooth muscle cell, platelet and other cells to activate, which precipitates dysfunction of the cells and therefore contributes to the development of atherosclerosis. This article briefly reviews the reseach progress in BKca participating in the development of atherosclerosis.
作者 莫显刚 罗兴林
机构地区 泸州医学院附属医院心内科
出处 《基础医学与临床》 CSCD 北大核心 2008年第11期1216-1218,共3页 Basic and Clinical Medicine
基金 四川省自然科学基金(04jy029-019-277)
关键词 大电导钙激活钾通道 动脉粥样硬化 big conductance Ca^2＋ -activated K^＋ channel atherosclerosis
分类号 R543.5 [医药卫生—心血管疾病]
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参考文献12

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二级参考文献3

共引文献1

同被引文献7

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基础医学与临床
2008年 第11期

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