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基于RCS大鼠模型的视网膜色素变性治疗 被引量：2

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摘要 视网膜色素变性是一类以光感受器细胞及色素上皮细胞功能丧失为共同表现的疾病,具有遗传倾向性,通过选择不同的视网膜色素变性(relinitis pigmentosa,RP)动物模型可以针对不同遗传方式的RP进行研究,皇家外科学院(royal college surgeons,RCS)大鼠是常染色体隐性遗传的经典动物模型,现将基于RCS大鼠模型的RP治疗研究进展综述如下。
作者 张萌 莫晓芬
机构地区 复旦大学附属眼耳鼻喉科医院眼科
出处 《中国眼耳鼻喉科杂志》 2008年第6期398-400,共3页 Chinese Journal of Ophthalmology and Otorhinolaryngology
关键词 视网膜色素变性 大鼠模型 治疗 常染色体隐性遗传 色素上皮细胞 光感受器细胞 遗传方式 动物模型
分类号 R774.1 [医药卫生—眼科]
  • 相关文献

参考文献25

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二级参考文献10

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共引文献2

同被引文献53

  • 1张良,唐仕波,黄冰,陈系古,马静,赖英荣.胚胎干细胞C3B鼠视网膜下腔移植分化研究[J].中国病理生理杂志,2006,22(7):1421-1424. 被引量：4
  • 2李波,张波涛,李传课,彭爱国,皮穗.滋阴明目丸治疗湿性老年性黄斑变性的临床观察[J].中国中医眼科杂志,2007,17(6):311-314. 被引量：21
  • 3刘东宁,阴正勤,吴楠,王艳华,翁传煌.大鼠骨髓间充质干细胞体外分化为视网膜神经节样细胞的实验研究[J].眼科研究,2007,25(12):900-903. 被引量：7
  • 4Quigley HA,Broman AT. The number of People with glaucoma worldwide in 2010 and 2020[J].{H}British Journal of Ophthalmology,2006,(03):262-267.
  • 5Schmeer CW,Wohl SG,Isenmann S. Cell-replacement therapy and neural repair in the retina[J].{H}Cell and Tissue Research,2012,(01):363-374.
  • 6Singh MS,Maclaren RE. Stem cells as a therapeutic tool for the blind:biology and future prospects[J].{H}PROCEEDINGS BIOLOGICAL SCIENCES/THE ROYAL SOCIETY,2011,(1721):3009-3016.
  • 7Baker PS,Brown GC. Stem-cell therapy in retinal disease[J].{H}Current Opinion Ophthalmology,2009,(03):175-181.
  • 8Lund RD,Wang S,Klimanskaya I. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats[J].{H}CLONING AND STEM CELLS,2006,(03):189-199.
  • 9Kicic A,Shen WY,Wilson AS. Differentiation of marrow stromal cells into photoreceptors in the rat eye[J].{H}Journal of Neuroscience,2003,(21):7742-7749.
  • 10Pinilla I,Cuenca N,Sauvé Y. Preservation of outer retina and its synaptic connectivity following subretinal injections of human RPE cells in the Royal College of Surgeons rat[J].{H}EXPERIMENTAL EYE RESEARCH,2007,(03):381-392.

引证文献2

二级引证文献11

中国眼耳鼻喉科杂志
2008年 第6期

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