男性腹膜后原发性生殖细胞肿瘤14例临床分析

Clinical analysis of 14 male patients with retroperitoneal primary germ cell tumors

目的分析男性腹膜后生殖细胞肿瘤的临床特征、治疗和影响预后的因素。方法对1984～2006年肿瘤医院收治的14例男性腹膜后原发的生殖细胞肿瘤患者进行回顾性分析,生存率计算采用Kaplan-Meier生存曲线,生存率的比较采用Log-rank检验。结果14例患者总的1、3、5年生存率分别为70%、44%和44%。精原细胞瘤患者1、3、5年生存率分别为80%、80%和80%,非精原细胞瘤患者1、3、5年生存率分别为65%、16%和16%。多因素分析显示治疗后是否达到CR是影响预后的独立因素(P=0.037)。结论腹膜后原发的生殖细胞肿瘤对放疗、化疗敏感,与原发于睾丸的生殖细胞肿瘤类似。综合治疗可提高患者生存,改善预后。

Objective To analyze the clinical characteristics, treatment, and prognostic factors of retroperitoneal primary germ cell tumors （GCTs）. Methods Totalhy 14 male patients with retroperitoneal GCTs treated from 1984 -2005 were retrospectively reviewed. The survival rate was calculated with Kaplan - Meier method and log-rank test. Results The 1-, 3-, and 5-year survival rates were 70%, 44%, and 44% for all patients, 80%, 80%, and 80% for seminoma, and 65%, 16%, and 16% for non-seminoma, respectively. Achieving complete response （CR） was the independent prognostic factor （ P = 0. 037）. Conclusion Retroperitoneal primary GCTs were similar to testis primary GCTs. The treatment outcome and survival in patients with retroperitoneal GCTs can be improved by multi-modality therapy.