期刊文献+

恶性肿瘤的个性化治疗 被引量:5

下载PDF
导出
摘要 恶性肿瘤具有异质性,这种异质性要求对恶性肿瘤患者必须提供个性化治疗。基于肿瘤标志物的分子分型、分子诊断和分子预后是个性化治疗的前提,高效且毒副作用小的分子靶向药物治疗是个性化治疗的关键,组学技术则为大量开发肿瘤标志物和新的靶向药物提供了有效的方法和手段。如何将这些分子生物学的理论和技术应用于临床并使肿瘤患者获益则是肿瘤转化研究的主要内容。本文将就肿瘤标志物、组学技术和肿瘤转化研究在肿瘤个性化治疗中的作用进行扼要综述。
作者 吴冠青 孙燕
出处 《癌症进展》 2008年第6期562-578,共17页 Oncology Progress
  • 相关文献

参考文献4

二级参考文献10

  • 1宋三泰.乳癌内分泌治疗应该注意的几个问题[J].中国实用外科杂志,1997,17(2):70-72. 被引量:6
  • 2储大同.生物和基因治疗[A].孙燕周际昌主编.临床肿瘤内科治疗手册:第4版[C].北京:人民卫生出版社,2003.74-89.
  • 3Martin TJ, Moseley JM. Mechanisms in the skeletal complications of breast cancer. Endocr Relat Cancer, 2000,7: 271-284.
  • 4Miller AB, Hoogstraten B, Staquet M, et al. Reporting results of cancer treatment. Cancer, 1981,47 : 207-214.
  • 5Hortobagyi GN. Novel approaches to the management of bone metastases in patients with breast cancer. Semin Oncol, 2002, 29:134-144.
  • 6Mouridsen H, Gershanovich M, Sun Y, et al. Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase Ⅲ study of the International Letrozole Breast Cancer Group. J Clin Oncol, 2001,19:2596-2606.
  • 7Robertson J, Howell A, Buzdar A, et al. Static disease on anastrozole provides similar benefit as objective response in patients with advanced breast cancer. Breast Cancer Res Treat, 1999,58: 157-162.
  • 8Kazuhiro Yoshida,Kazuaki Tanabe,Hideaki Ueno,Kouji Ohta,Jun Hihara,Tetsuya Toge,Masahiko Nishiyama. Future prospects of personalized chemotherapy in gastric cancer patients: results of a prospective randomized pilot study[J] 2003,Gastric Cancer(1):82~89
  • 9宋三泰,江泽飞.乳腺癌内分泌治疗的现状及应用策略[J].中华肿瘤杂志,1999,21(4):312-313. 被引量:20
  • 10闫敏,宋三泰,江泽飞,刘晓晴,李彦博,徐建明,刘芳,申戈,孙君重.乳腺癌骨转移的临床病程[J].中国骨肿瘤骨病,2003,2(4):221-224. 被引量:30

共引文献55

同被引文献47

  • 1Roukos DH.Personalized cancer diagnostics and therapeutics.Expert Rev Mol Diagn,2009,9:227-229.
  • 2Coe BP,Chad R,Lockwood WW,et al.Evolving strategies for global gane expression analysis of cancer.J Cell Physiol,2008,217:590-597.
  • 3Cunliffe and Frank Ltd.The war on cancer[M/CD].New York,Cunliffe and Frank Ltd,1997.
  • 4Cohen MM,Diamond JM.Mdical research Are we losing the war on cancer?.Nature,1986,323(6088):488-489.
  • 5Jemal A,Siegel R,Ward E,et al.Cancer statistics,2007.CACancer J Clin,2007,57(1):43-66.
  • 6Adams JU.Building the bridge from bench to bedside.Nature Reviews Drug Discovery,2008(7):463-464.
  • 7Cullen JP,Glynn C,Murtagh E,et al.Auditing a new lung cancer service.Ir Med J,2004,97(9),281.
  • 8McDavid K,Lee J,Fulton IP,et al.Prostate cancer incidence and mortality rates and trends in the United States and Canada.Public Health Rep,2004(119):174.
  • 9Miller DC,Hafez KS,Stewart A,et al.Prostate carcinoma presentation,diagnosis,and staging,an update from the National Cancer Date Base.Cancer,2003(98):1169-1178.
  • 10Briasoulis E,Tolis CBergh I,et al.ESMO rninumum clinical recommendations for diagnosis,treatment and tollow-up of cancers of unlcnown primary site(CUP).Ann Oncol,2005,16 (Soppl 1):175.

引证文献5

二级引证文献33

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部