恶性肿瘤患者消化道念珠菌感染的临床分析

Risk Factors and Infection Characteristics of Albicans Monilia in Malignant Tumor of Esophagus Patients

目的了解恶性肿瘤患者消化道白色念珠菌感染的临床特点,分析白色念珠菌感染的危险因素,为预防和监控感染提供参考依据。方法回顾性总结2001年1月—2007年12月的恶性肿瘤住院患者并发消化道念珠菌感染的相关资料。结果418例恶性肿瘤念珠菌感染率为21.05%,念珠菌类型主要是白色念珠菌(71.43%),其次为光滑念珠菌(15.24%)。最易发生感染的部位是口腔及食道,占59.05%(62/105)。性别对念珠菌感染没有影响,主要危险因素为肿瘤分期、住院时间、接受放化疗、长期大量使用广谱抗生素和激素、各种侵入性诊疗操作的应用等。结论念珠菌是临床重要的条件致病菌,免疫力低下是恶性肿瘤患者发生念珠菌感染的重要原因,以消化道发生率高,必须重视念珠菌感染的防控。

Objective To explore risk factors and infection characteristics of albicans monilia in malignant tumor of esophagus patients. Methods A total of of 418 malignant tumor of esophagus patients with albicans monilia infection from January 2001 to December 2007 were reviewed. Results Monilias were found in 88 of 418 patients （21.05%） ; C. albicans accounted for 71.43% , C. glabrata 15.24%. The most commonly involved site was the oral cavity and esophagus （59.05%）. Sex was not significant. Multivariate analysis showed that long time hospitaliation, late tumor stage, concurrent chemotherapy and radiotherapy, usage of hormone and antifungal, and invasive treatment operation were significant predisposing factors for infection of albieans monilia. Conclusion Monilia is one of the important clinical conditioned pathogens. We should consider enhancing the immunity of patients with esophageal cancer and pay attention to the prevention of monilia infection.