孟鲁司特与小剂量倍氯米松治疗咳嗽变异性哮喘的疗效比较

Effectiveness of Montelukasta Versus Low Dose of Beclometasone in Treatment of Cough Variant Asthma

目的:比较孟鲁司特与小剂量倍氯米松、联用孟鲁司特和小剂量倍氯米松治疗咳嗽变异性哮喘的疗效。方法:选择50名咳嗽变异性哮喘患者,随机分成三组:A组予孟鲁司特10mg每晚睡前口服,B组予倍氯米松气雾剂250μg早晚各吸1吸,C组联合口服孟鲁司特及吸入倍氯米松。每组按需吸入沙丁胺醇气雾剂。观察试验前后临床症状评分和肺功能变化,及治疗期间白天咳嗽评分、夜间睡眠评分、沙丁胺醇气雾剂的用量、PEF昼夜变异率。结果:治疗后各组临床症状、PEF昼夜变异率均明显改善,FEV1无明显升高。各治疗阶段C组症状、PEF昼夜变异率较其它组均明显改善。结论:单用孟鲁司特与小剂量吸入激素治疗咳嗽变异性哮喘疗效相当,两药联合可加强并加快疗效。

Objective： To compare the effectiveness of montelukast, low dose of beelometasone and combination of above - mentioned drug in treatment of cough variant asthma （ CVA）. Method： 50 patients with CVA were randomly divided into 3 groups：group A assigned treatment with montelukast, 10 mg for oral use at bedtime, group B with a low dose of beclometasone, 250μg for inhalation twice daily , group C with abovementioned drug. Every group can use salbutamol aerosol when need. Clinical symptom scores and lung function were observed before and after experiment, as well as daytime symptom scores, oeturnal symptom scores, use frequency of salbutamol, PEF diurnal variation during treatment period. Result： Clinical symptom and PEF diurnal variation were ameliorated significantly in every group after the course of treatment. , but FEV1 had not be ameliorated significantly. At every step of treatment, the symptom and PEF di- urnal variation were ameliorated more predominantly in group C than the other groups. Condusion： The effect of montelukst and low of inhaled cortieosteroids （ICS） in treatment of CVA is similar, combination two tyes of drug can enhance and accelerate therapeutic effect.