急性心力衰竭患者血浆B型尿钠肽水平变化的临床研究

Clinical analysis of the change of plasma BNP levels in patients with heart failure

目的:探讨急性心力衰竭(HF)患者血浆B型尿钠肽(BNP)改变及其临床意义。方法:对48例HF患者(HF组)和50例健康者(对照组),行超声心动图检查测定左室射血分数(LVEF),同时测定血浆BNP水平,心衰患者治疗3～4周后复查超声心动图和BNP,观察治疗前后各指标的变化及BNP水平与LVEF的相关性。结果:(1)HF组血浆BNP水平明显高于对照组(P<0.01);(2)HF控制后BNP水平明显降低(P<0.01);(3)BNP浓度与LVEF有很好的相关性(P<0.01)。结论:血浆BNP水平对HF的诊断、严重程度和预后评价有重要价值。

Objective：To study the clinical significance of the changes of plasma BNPlevels in patients with heart failure（HF）. Methods：The plasma BNP levels in 48 patients with HF（NYNA Ⅱ. Ⅲ .Ⅳ）and 50 controls were determined with rapid fluorescence immunoassay.Results：The plasma BNP levels in patients with HF were significantly higher than those in centrels（P〈0.01）. The plasma BNP level was low when HF was cured（P〈0.01）.The simple relative analysis indicated that the plasma BNP levels were negatively correlated to LVEF（r=-0.887,P〈0.01）.Condusion：Determination of plasma BNP levels in patients with HF was helpful to the study of the severity and prognosis of disease.