尿路感染者病原体检测及耐药性分析

Distribution and Drug Resistance of Pathogens in Urinary Tract Infection

目的探讨尿路感染的病原菌分布及耐药情况,指导临床合理用药。方法对医院2006年1月～2007年12月间住院及门诊尿路感染患者尿培养分离出的391株病原菌进行鉴定和药物敏感性分析。结果391株尿路感染的菌株中以革兰阴性菌为主,其中以大肠埃希菌最常见,其次为肺炎克雷伯菌、铜绿假单胞菌;革兰阳性菌中以肠球菌属为主;真菌感染的数量明显增加;细菌对各种抗菌药物有不同程度的耐药率,表现为多重耐药。结论尿路感染常见病原菌耐药严重,临床应根据药物敏感性试验结果有针对性地筛选敏感药物进行治疗。

Objective To analyze the pathogenic bacteria distribution and antibiotic resistance in our hospital and to provide the scientific basis for the clinical rational use of antibiotics. Methods 391 pathogenic isolates cultivated in the samples collected from Jan. 2006 to Dec. 2007 were identified and analyzed for the antibiotic sensitivity tests. Results The pathogenic bacteria mainly consisted of Gramnegatives, among which Escherichia coil was the most frequent, the others in turn were Klebsiella pneumoniae and Pseudomonas aeruginosa. Enterococcns was the most common among Gram- positives. Fungal infection obviously increased. The bacteria showed different antibiotic resistance rate and muhidrug resistance. Conclusion The high antibiotic resistance of commonly encountered pathogens is a serious problem and the clinic should reasonably choose the antibiotics.according to the test results of the pathogen sensitivity to drugs.