放射性核素显像在轻度认知功能障碍中的应用价值

Applications of radionuclide imaging in mild cognitive impairment

轻度认知功能障碍（MCI）患者存在进展为痴呆的高度危险，早期发现将进展为阿尔茨海默病（AD）的MCI有重要的实验研究和临床意义。放射性核素显像已广泛应用于研究MCI脑代谢和脑血流量以及评价MCI的预后。综述了近年来放射性核素显像以及与载脂蛋白E基因型分析等其他方法联合使用对于MCI预后判断的价值。

The risk for conversion to dementia is much higher in individuals with mild coghitived impairmaent （MCI） . The early detection of MCI individuals who will later convert to Alzheimer disease is an important issue for both clinical and research interests. Radionuclide imaging has been broadly used to study cerebral metabolism and blood flow, as well as predicting the prognosis of MCI. This review summarizes the results of these studies assessing the predicting value of radionuclide imaging used alone and with other methods in recent years.