66例小肠恶性肿瘤的临床病理学和免疫组织化学研究

A clinicopathological and immunohistochemical study on 66 cases of primary malignant tumors of the small intestine

本文观察66例小肠恶性肿瘤的病理组织形态学，按WHO肿瘤新分类总结其病理组织类型；并采用链菌素亲生物素-过氧化酶连接法（streptavidinperoxdaseconjugataedmethod简称SP法），使用6种抗体（keratin、CEA、S－100、vmentin、myoslobin、LCA等）免疫组织化学染色研究。本组材料证明：原发小肠恶性肿瘤小肠癌多见，尤以二十指肠腺癌最常见；而恶性淋巴瘤居第二位，以回肠恶性淋巴瘤最常见。作者对小肠肿瘤组织学类型和恶性淋巴瘤诊断问题进行详细讨论。

66 cases of prirnary malignant turnors in the small intestine were observed and their clinicopathologicalfeatures were described. They were classified by International Histological Typing (WHO, 1989 ). Streptavidinperoxidase conjugated method (S-P Method) with antibodies (keratin, CEA, S-100,vimentin myoglobin, LCA)was used to investigate these tumors. The data confirm that carcinoma is the rnost common tumor in primary malignant turnors of the small intestine. Adenocarcinoma of the duodenum is the most prevalent tumor, while the malignant lymphorna is the second tumor. Lymphosarcorna is commonly located in ileum. At last, the authors discussed the histological type of the small intestinal turnors, and also discussed the problems of diagnosis of the malignant lymphoma.