福辛普利联合氨氯地平治疗原发性高血压

Fosinopril and Amiodipine on Treatment of Primary Hypertension

目的观察福辛普利联合氨氯地平治疗原发性重度高血压的作用及对肝肾功能的影响。方法100例原发性重度高血压的患者随机分2组,观察组口服福辛普利和氨氯地平,对照组口服氨氯地平,治疗12个月,随访时间为1 a,以24 h动态血压、血清天冬氨酸转氨酶、丙氨酸转氨酶、谷氨酰转肽酶、尿素氮、肌酐,24 h尿蛋白定量检查结果,进行2组的对比。结果2组患者治疗后血压均有显著下降(P<0.01),观察组下降的幅度明显高于对照组(P<0.05)。观察组24 h尿蛋白定量无显著变化(P>0.05),治疗组24 h尿蛋白定量明显下降(P<0.05)。2组天冬氨酸转氨酶,丙氨酸转氨酶,γ-谷氨酰转肽酶,尿素氮,肌酐治疗前后无显著变化(P>0.05)。结论福辛普利联合氨氯地平降压效果优于单药应用氨氯地平,不增加肝肾功能损伤程度,并可减少尿蛋白。

[ Objective] To observe the effect of Fosinopril and Amlodipine on treatment of Hypertension and the influence to liver and renal function. [ Methods] 100 patients with primary hypertension were randomly divided into2 groups, observation group received combination of Fosinopril and Amlodipine orally, and control group received Amlodipine orally, for 12-month treatment, follow-up duration for 1 year. The 24-hour ambulatory blood pressure, serum GOT, GFF, GPT, BUN, Cr and 24HUPQ were observed and the results were compared. [ Results] The blood pressure decreased significantly in two groups after treatment （P 〈 0.01 ）, and decrease amplitude was more obviously in the experiment group than in the control group （ P 〈 0.05 ）. 24HUPQ had no significant change in the control group （ P 〉 0.05 ）, but that in observation group decreased obviously （ P 〈 0.05 ）. GOT, GPT,-GPT, BUN and Cr had no significant change in two groups （P 〉0.05） . [ Conclusion] The effect of combination of Fosinopril and Amlodipine surpass the single use of Amlodipine. It does not increase liver and renal function injury and can reduce urine protein.