血清尿酸与非高密度脂蛋白胆固醇检测在冠心病预测、评价中的意义

Significance of the Detection of Serum Uric Acid and Non-High Density Lipoprotein Cholesterol in the Prediction and Evaluation of Coronary Heart Diseases

目的分析血清尿酸(UA)、非高密度脂蛋白胆固醇(non-HDL-C)及其他血脂指标在冠心病患者中的变化及意义。方法随机选取冠心病(CHD)患者293例及147例体检健康者(对照组),测定血清尿酸、血脂,计算non-HDL-C值,采用SPSS软件进行统计学分析。结果CHD组UA、non-HDL-C、甘油三酯(TG)浓度明显高于对照组(P<0.01);低密度脂蛋白胆固醇(LDL-C)、脱辅基蛋白B(aPoB)浓度高于对照组(P<0.05);载脂蛋白-AI(aPoA-I)、高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组(P<0.01);经多元素logistie回归分析发现non-HDL-C与CHD发生关系最密切,其次为UA、TG、LDL-C等。结论non-HDL-C比LDL-C对CHD的发生有更好的预测评价作用。高尿酸血症可能是CHD发生的又一危险因素。

[ Objective ] To analyze the clinical value of serum uric acid, non-high density lipoprotein cholesterol （ HDL C ）and other blood index among the patients of coronary heart diseases （CHD）. [ Methods] 293 CHD cases and 147 healthy people were stochastically collected ; detection was made on their serum uric acid and blood lipid; non HDL C value was calculated ; statistical anal- ysis was made with SPSS software. [ Results] The levels of serum uric acid, non HDL C value and total cholesterol （TC） of the CHD group were obviously higher than that of the control （ P 〈 0.01 ） ; the levels of low density lipoprotein cholesterol （ LDL C） and aPoB were higher than that of the control （ P 〈 0.05 ） ; the levels of aPoA-I and HDL C were significantly lower than that of the con- trol （ P 〈0.01 ） ; the logistic regression analysis found that non HDL C had the closest relationship with CHD, then with UA, TG, LDL C and so on. [ Conclusion] Non HDL C can more effectively predict and evaluate the occurrence of CHD than LDL C; high serum UA might be another risk factor for CHD.