接种狂犬病疫苗后抗体阳转情况及其相关因素分析

Seroconversion of Antibody after Rabies Vaccine Inoculation and Its Related Factors

目的探讨接种狂犬病疫苗后抗体阳转率及其相关因素。方法2007年1-12月2721人全程接种狂犬病疫苗5剂,根据季节、性别和年龄对所有接种者进行分组,比较各组人群接种狂犬病疫苗后的抗体阳转情况。结果不同季节和性别接种者抗体阳转率无统计学差异(P>0.05);抗体阳转率与年龄呈负相关(r=-0.99,P<0.05),直线方程为Y=99.69-0.137X。结论接种狂犬病疫苗后,年龄、季节对抗体阳转无明显影响作用,但抗体阳性率随年龄的增长呈下降趋势;注射疫苗期间,应对接种者给予生活习惯和药物使用等方面的指导。

Objective To investigate the seroconversion rate of antibody after rabies vaccine inoculation and the its related factors. Methods Two thousands seven hundreds and twenty-one cases inoculated with a total of 5 injections of rabies vaccine from January 2007 to December 2007 were recruited in this study and divided into different group according to inoculation season, inoculator＇s gender and age. The seroconversion rate of antibody after rabies vaccine inoculation among different group were compared. Results There was no statistical difference of seroconversion rates of antibody among inoculators with different occulation season and gender（ P 〉0.05）. There was negative correlation between seroconversion rate of antibody and inoculator＇s age （ r =-0.99, P 〈0.05）. Conclusion Inoculator＇s age and inoculation season has no obvious influence on seroconversion of antibody after rabies vaccine inoculation. But positive rate of antibody has a decreasing trend with the increased age of inoculator. During vaccine inoculation, guidance about living habits and medication should be provided to inoculators.