STAT3及VEGF在子宫内膜癌组织中的表达研究

Significance and expression of VEGF and STAT 3 in endometrial carcinoma by tissue chip technique

目的:探讨信号传导与转录激活因子3(STAT3)和血管内皮生长因子(VECF)的表达与子宫内膜癌临床病理学特征之间的关系及其表达的相关性。方法:采用免疫组化法检测VEGF及STAT3在子宫内膜癌组织中的表达。结果:在子宫内膜癌组织中VEGF、STAT3阳性率分别为70.2%、71.9%。癌组织中VEGF和STAT3的表达均与病理分级、临床分期、淋巴结转移有相关性(P<0.05),子宫内膜癌组织中VEGF与STAT3表达呈正相关(P<0.05)。结论:VEGF和STAT3在子宫内膜癌中过度表达,STAT3与子宫内膜癌的病理分级、临床分期及淋巴结转移有关,STAT3可能通过上调VEGF的表达,促进子宫内膜癌组织中新生血管的形成,在子宫内膜癌的发生发展中起重要作用。

Objective： To investigate the relationship between the expression of VEGF and STAT3 and the clinicopathological factors of endometrial cancer and study the correlations between VEGF and STAT 3. Methods： The VEGF and STAT3 expressions in cancer of endometrium were detected by immunohistochemical staining. Results： The positive rates of VEGF and STAT3 in endometrial carcinoma were 70. 2%, 71. 9% respecttvely. The expression of STAT3 and VEGF had relation with histological grade, TNM stage, lymph node metastasis in endometrial carcinoma. The differences reached significant values （P 〈 0. 05）. The two had no relation with age. Positive correlation was found between the expression of STAT3 and VEGF （ P 〈 0. 05 ） in endometrial carcinoma. Conclusion： STAT3 and VEGF are over - expressed in endometrial carcinoma. The expression of STAT 3 has relation with histological grade, TNM stage, lymph node in endometrial. VEGF might be up - regulated by STAT3 to result in tumor angiogenesis. Therefore, STAT3 may play an important role in the carcinogenesis and progression of endometrial carcinoma.