期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

系统性红斑狼疮与Ⅰ型干扰素关系 被引量：3

下载PDF
导出
摘要 系统性红斑狼疮(SLE)是多系统的自身免疫结缔组织病,具有广泛的临床表现,以抗核抗体的产生为特征。其致病因素主要包括激素、环境与遗传三方面。Ⅰ型干扰素(interferon,IFN)系统在系统性红斑狼疮的发病机制中起着重要作用,研究表明SLE患者IFN-α血清水平升高,慢性感染和恶性病患者经过长期IFN-α治疗能够引发SLE综合征,进一步证明了Ⅰ型IFN系统在SLE发病机制中的关键作用。本文就SLE的概况、Ⅰ型IFN系统与SLE的关系以及SLE的诊断和治疗作一综述,另外还对SLE的治疗前景进行了展望。
作者 曾庆娣 潘玉琴 王书奎
机构地区 南京医科大学附属南京第一医院中心实验室 南京师范大学生命科学学院
出处 《国际检验医学杂志》 CAS 2008年第11期1019-1020,1025,共3页 International Journal of Laboratory Medicine
基金 南京市医学科技发展项目(编号YKK07033)
关键词 红斑狼疮 系统性 干扰素Ⅰ型 诊断 治疗
分类号 R593.241 [医药卫生—内科学] R446.62 [医药卫生—诊断学]
  • 相关文献

参考文献13

  • 1Vallin H,Blomberg S,AIm GV,et al. Patients with systemic lupus erythematosus (SLE) have a circulating inducer of interferon alpha (IFN-alpha) production acting on leucocytes resembling immature dendritic cells [J]. Clin Exp Immunol, 1999,115(1) :196-202.
  • 2Blomberg S,Eloranta ML,Magnusson M,et al. Expression of the markers BDCA-2 and BDCA 4 and production of interferon-alpha by plasmacytoid dendritic cells in systemic lupus erythematosus [J]. Arthritis Rheum, 2003,48(9) :2524-2532.
  • 3Robak E, Smolewski P,Wozniacka A, et al. Relationship between peripheral blood dendritic cells and cytokines involved in the pathogenesis of systemic lupus erythematosus [J]. Eur Cytokine Netw, 2004,15(3) :222-230.
  • 4Savarese E,Chae OW,Trowitzsch S, et al. U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7[J]. Blood, 2006,107 (8) : 3229-3234.
  • 5Heinlen LD, McClain MT, Merrill J, et al. Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms [J]. Arthritis Rheum, 2007,56(7) :2344-2351.
  • 6Rifkin IR,Leadhetter EA,Buseoni L,et al. Toll-like receptors, endogenous ligands, and systemic autoimmune disease [J]. Immunol Rev, 2005,204 : 27-42.
  • 7Choi JJ, Reich CF 3rd, Pisetsky DS. The role of macrophages in the in vitro generation of extracellular DNA from apoptotic arid necrotic cells [J]. Immunology, 2005,]15(1):55-62.
  • 8Bave U, Vallin H, Alm GV, et al. Activation of natural interferon-alpha producing cells by apoptotic U937 cells combined with lupus IgG and its regulation by cytokines [J]. J Autoimmun, 2001,17 (1) :71-80.
  • 9Fessler BJ, Alarcon GS, McGwin G Jr, et al. Systemic lupus erythematosus in three ethnic groups: XVI. Association of hydroxychloroquine use with reduced risk of damage accrual [J]. Arthritis Rheum, 2005,52(5) :1473 1480.
  • 10Schieppati A,Remuzzi G. Novel therapies of lupus nephritis [J].Curr Opin Nephrol Hypertens, 2008,17(2) : 156-161.

同被引文献31

  • 1邹自英,李素华,陈莉.13种自身抗体检测对SLE的诊断价值及临床意义[J].细胞与分子免疫学杂志,2007,23(5):443-444. 被引量：24
  • 2Horvat Z,Cike N,Krajina L,et al.ANA-negative systermic lupus erythematosus[J].Lijec Vjesn,1997,109(8-9):301-302.
  • 3Berden JH,Grootscholten C,Jurgen WC,et al.Lupus nephritis:an ucleosome waste disposal defect[J].J Nephrol,2002,15(Suppl 6):1-10.
  • 4Heathcote EJ.Management of primary biliary cirrhosis.The American Association for the study of Liver Diseases Practice Guidelines[J].Hepatology,2000,31(20):1005-1013.
  • 5Neuberger J,Thomson R.PBC and AMA-what is the connection[J]?Hepatology,1999,29(19):271-276.
  • 6Strickland FM,Richardson BC.Epigenetics in autoimmunity-DNA methylation in systemic lupus erythematosus and beyond Autoimmunity[J].Epigenetics in human autoimmunity,2008,41(4):278-286.
  • 7Sekigawa I,Kawasaki M,Ogasawara H,et al.DNA methylation:its contribution to systemic lupus erythematosus[J].Clin Exp Med,2006,6(3):99-106.
  • 8Perl A,Nagy G,Koncz A,et al.Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE[J].Autoimmunity,2008,41(4):287-297.
  • 9Meyer O.Interferons and autoimmune disorders[J].Joint Bone Spine,2009,76(5):464-473.
  • 10Remmers EF,Plenge RM,Lee AT,et al.STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus[J].N Engl J Med,2007,357(10):977-986.

引证文献3

二级引证文献4

国际检验医学杂志
2008年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部