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环境污染物对人体生物有效性测定的胃肠模拟研究现状 被引量：39

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摘要 环境污染物对人体健康产生了巨大的危害,污染物的生物利用度是人体健康风险评估中的关键因子.本文系统介绍了模拟胃肠消化系统测定污染物对人体生物有效性的实验方法、主要控制条件、影响生物有效性的因素及其在健康风险评估研究中的应用.同时对其在开展有机污染物的生物有效性及其代谢研究、Caco-2细胞在该类研究中的应用以及体外模拟方法的验证方面进行了展望.
作者 张东平 余应新 张帆 王德庆 吴明红 盛国英 傅家谟
机构地区 上海大学环境与化学工程学院环境污染与健康研究所 上海大学环境与化学工程学院上海射线应用研究所 中国科学院广州地球化学研究所
出处 《科学通报》 EI CAS CSCD 北大核心 2008年第21期2537-2545,共9页 Chinese Science Bulletin
基金 国家重点基础研究发展计划(批准号:2008CB418205) 国家自然科学青年基金(批准号:20807026) 上海市高校优秀青年教师后备人选项目资助
关键词 体外实验 胃肠道 生物有效性 健康风险评价
分类号 X503 [环境科学与工程—环境工程]
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参考文献96

  • 1Wragg J, Cave M R. In vitro methods for the measurement of the oral bioaccessibility of selected metals and metalloids in soils: A critical review. Technical Report. Environmental Agency, UK. 2002.
  • 2Oomen A G, Rompelberg C J M, Bruil M A, et al. Development of an in vitro digestion model for estimating the bioaccessibility of soil contaminants. Arch Environ Contam Toxicol, 2003, 44(3): 281--287.
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二级参考文献59

  • 1Ruby M V, Schod R., Brattin W et al., Advances in Evaluating the Oral Biovailability of Inorganics in Soil for Use in Human Health Risk Assessment. Environmental Science and Technology, 1999, 33 (21) :3697--3705.
  • 2Ruby M V, Davis A, Schod R et al., Estimation of Lead and Arsenic Bioavaibility Using a Physiologically Based Extraction Test. Environmental and Technology, 1996, 30 (2) :422--430.
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  • 8Healy M A, Harrison P G, Aslam M et al., Lead Sulphide and Traditional Preparations: Routes for Ingestion, Solubility and Reactions in Gastric fluid. Journal of Clinidcal Hospital Pharmacy, 1982, 7:169--173.
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  • 10USEPA, Guidance Manual for the Integrated Exposure Uptake Biokinetic Model for Lead in Children (IEUBK). Prpared the Technical Review Workgroup for Lead for the Office of Emergency an Remedial Response, USEPA. Publication Number 9285.7-15-1 EPA 540-R-93-081 PB93-963510, with Document Production Assistance from Envir. Criteria and Assessmerit Office, USEPA, 1994, Research Triangle Park, NC 27711.

共引文献72

同被引文献790

引证文献39

二级引证文献315

科学通报
2008年 第21期

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