高压氧预处理对高原人体耐缺氧抗疲劳的研究

INVESTIGATION OF HYPERBARIC OXYGEN PRECONDITIONING ON ANOXIC RESISTANCE AND ANTI-WEARINESS AT HIGH ALTITUDE

目的:探讨高压氧预治疗(HBO)对高原人体耐缺氧抗疲劳的影响。方法:①海拔3700m的20名习服男青年,于HBO预处理前(对照组,)、预处理2次(A组,10人)和预处理5次(B组,10人)后的第2、第8d和第2、第5d作自身对比运动负荷实验,运动结束后测血中检测超氧化物歧化酶(SOD)、丙二醛(MDA)、乳酸(BLA)、尿素氮(BUN)、一氧化氮(NO)及其合酶(NOS)的含量。②20名青年自海拔1400m乘车抵达海拔3700m,分为HBO组(10人)和对照组(10人),HBO组连续HBO预处理3d,每天1次,第4d两组同时乘车进驻海拔5380m,到达后第5d清晨采空腹静脉血。③29名青年分为HBO组(11人)和对照组(18人),HBO组于进入高原前2d在海拔1400m接受HBO预处理,每天1次,连续2d,第3d两组同时乘车进驻海拔5200m,到达后第5d清晨采空腹静脉血;结果:①在海拔3700mHBO可使SOD、NO、NOS增高,BLA、BUN、MDA降低,有非常显著性差异(P<0.01),并可持续保留8d以上。②进驻海拔5200m和5380m的青年,实验组较对照组SOD、NO、NOS增高,BLA、BUN、MDA降低,有显著性差异(P<0.01或0.05)。结论:HBO可增强高原机体抗氧化酶活性和乳酸清除能力,具有抗疲劳作用,且这种效应可持续8d以上。

Aim： To explore the influence of hyperbaric oxygen（HBO） preconditioning on anoxic resistance and anti-weariness at high altitude. Methods： （1）SOD, MDA, NO, NOS, BLA and BUN of 20 youths living at 3 700 m altitude for half year were tested, then they were divided into group A（ n = 10, received HBO pretreatment twice） and group B（ n = 10, received HBO pretreatment 5 times） randomly. They were asked to pedal the EMG-bicycle-ergometer at the second and eighth day, and then the same items were tested. （2）29 youth who would go to Astronomical SPOt（5 200 m） were randomly divided into group HBO（ n = 11, received HBO pretreatment once per day for 2 days at Yecheng（ 1 400m）） and comparison group（ n = 10）. When they reached I Astronomical Spot, thematic biochemical index were investigaited. （3）When 20 youth reached Thirty Milepost Barracks（3 700 m） at the second day in their way to Immortal Gulf（5 380 m） from Yecheng were randomly divided into group HBO（ n = 10, received HBO pretreatment once per day for 3 days） and comparison group（ n = 10）. When they reached Immortal Gulf, the thematic biochemical index were investigaited. Results： （1）SOD, NO, NOS were increased and BLA, BUN, MDA were decrease in group A compared with that in group B until the eighth day, there was significant difference（P〈0.01）. （2）SOD, NO, NOS were increased and BLA, BUN, MDA were decrease in group HBO compared with that in comparison that in group, there was significant difference between groups（P〈 0.01, or P〈0.05）. Conclusion： HBO could enhance the activity of anti-oxidase and the cleared ability of lactic acid, and the effect of anti-weariness could last for 8 days.