COMT Val^(158)Met多态型青年在数字工作记忆任务中的视觉事件相关电位的研究

STUDY ON VISUAL EVOKED RELATED POTENTIALS IN YOUNG ADULTS OF DIFFERENT COMT GENOTYPES BY USING A NUMERIC WORKING MEMORY TASK

目的:针对不同COMT基因型健康青年被试,进行连续3-back任务1h共12Block,探讨健康成人数字工作记忆能力变化情况。方法:将112名健康青年分组抽取出18名不同基因型作为被试,利用视觉事件相关电位P3来观测被试连续工作记忆任务中COMT基因多态型与脑皮层电生理的关系。结果:Val/Val基因型的被试P3波幅显著高于Val/Met基因型(P<0.01),但和Met/Met基因型被试的波幅无差异。结论:Val/Met基因型被试关联着最差的工作记忆任务的成绩,被试者的P3波幅和3-back任务成绩成正相关。

Ain： To explore the change of number working memory ability in healthy young adults, a continuous 3-back number working memory task were performed for an hour and 12 Blocks according to different COMT genotypes of young adults. Methods： 18 different genotype subjects were chosen from 112 healthy young adults, P3 event-related potentials was utilized to observe the relationship between this COMT polymorphism and cortical physiology in a continuous working memory task. Results： Subjects bearing the Val/Val homozygote had significantly higher mean P3 amplitudes than Val/Met heterozygote（ P 〈 0.01 ）, however, no significant differences in comparison to Met/Met homozygote. Conclusion： Val/Met Heterozygote subjects are associated with the poorest performance of working memory. There is a relationship between COMT genotype and P3 visual event-related potentials evoked from 3-back task.