23436例不同性别坐、卧位血液流变参考范围的建立

BLOOD RHEOLOGY ANALYSIS OF 23436 SAMPLES AND ESTABLISHMENT OF REFERENCE RANGE BY SITTING AND LYING POSITION

目的:建立健康人群不同性别坐、卧位血液流变参考范围。方法:组织31位志愿者进行坐、卧位配对血液流变检测;用SPSS13.O软件统计分析2002.7年至2006.7年医院数据库32854例血液流变资料,其中健康体检23436例、门诊6553例、住院2865例,以独立样本t检验比较不同体位、性别的差异,建立各自参考范围。结果:坐、卧位总体均数12项指标差异有统计学意义(P<0.01),以坐位为基线,卧位时各切变率、全血粘度、全血还原粘度、血浆粘度及红细胞压积等8项主要指标明显降低,平均降9.33%,而红细胞变形指数、电泳指数则上升,平均升6.49%。与自身坐、卧位配对实验结果一致。男、女性别差异有统计学意义(P<0.01)。结论:体位可引起血液流变各参数显著生理变异,建立不同性别坐、卧位各自参考范围,可提高约8%～10%诊断符合率,减少临床误诊。

Aim： To establish reference range of blood rheology for different gender by sitting and lying in healthy populations. Methods： In 31 volunteers blood were drawed in the postures of sitting and lying to measure blood rheology. Data（between July 2002 and July 2006） of 32854 samples（23436 check-up, 6553 out-pantient, 2865 in-pantient） were collected. Defferences between different postures and different gender were compared by Independ-Sample t-test with SPSS 13.0 software and each reference range of blood rheology was established. Results： In sitting and lying postures 12 parameters of blood theology showed great significance （P 〈 0.01 ）. 8 parameters such as whole blood viscosity, blood reduce viscosity, plasma viscosity, hematocrit, were decreased by 9.33 % on average while posture was changed from sitting to lying. But index of erythrocyte deformabilty, erythrocyte electrophoresis presented inverse correlation and were increased by 6.49% on average with the same posture change. Various parameters of blood rheology in diferent gender Showed great significance（P 〈 0.01 ）. Conclusion： There is significant difference in various parameters of blood theology in the posture change from sitting to lying. Reference ranges of blood rheology of different postures are established which may be used to decrease the rate of misdiagnosis by 8-10 percent.