染色体结构变异在胃癌发生发展中的作用

Role of chromosome structure variation in carcinogenesis and progression of gastric cancer

胃癌的发生是一个多因素多步骤过程,其中染色体结构异常而导致的抑癌基因的失活和癌基因的激活在这个过程中起了重要作用.因此,通过对染色体结构变异的研究寻找肿瘤相关的抑癌基因或癌基因成为胃癌及肿瘤学研究中的重要手段.本文将综述目前胃癌染色体结构异常研究进展,并从方法学上阐述几种分子遗传学及分子生物学常用手段在研究胃癌染色体结构变异中的作用,旨在为读者的实验研究提供有价值的参考.

The carcinogenesis of gastric cancer is a multifactor process with many steps, of which, both the losing activity of tumor suppressor genes resulting from the abnormal structure of the chromosomes, and the activation of the oncogenes play important roles in these process. Therefore, identification of the tumor suppressor gene and oncogene through researching on the structural chromosomal abnormality has become an important means for the research of gastric cancer and oncology. This paper reviews the researches on current progresses on structural chromosomal abnormality in gastric cancer, especially on the aspect of methodology, and explained the application of various molecular genetics and molecular biology means used in structural chromosomal abnormality research. This paper aimed at providing references for the choice of researching methods for the readers.