摘要
目的:检测水通道蛋白9(Aquaporin 9,AQP9)mRNA在子痫前期患者胎盘中的表达,以探讨AQP9在子痫前期发病机制中的意义。方法:用半定量逆转录聚合酶链反应(RT-PCR)技术检测正常妊娠(10例)、子痫前期(22例)剖宫产后胎盘中AQP9基因在转录水平的表达。结果:子痫前期组胎盘中AQP9 mRNA表达量较正常妊娠组显著升高(P<0.01)。结论:AQP9在子痫前期的发病中起着重要作用,可能与AQP9表达增加有关。
Objective： Investigating the expression of AQP9 mRNA by reverse transcription polymerasechain reaction （ RT - PCR） in the normal and preeclampsia placentas in order to evaluate the role of AQP9 in preeclampsia. Methods： RT - PCR was used to detect the AQP9 expression level in placentas of 22 preeelampsia cases and 10 normal cases after caesarean section delivery. Results： The expression of AQP9 was Significantly increased in the preeclampsia placentas compared to the normal ones （P 〈 0. 01 ） . Conclusion： The alteration of AQP9 mRNA expression in placenta plays an important role in the pathogenesis of preeclampsia.
出处
《中国妇幼保健》
CAS
北大核心
2008年第34期4902-4903,共2页
Maternal and Child Health Care of China
