摘要
目的:探讨妊娠期肝内胆汁瘀积症(intrahepatic cholestasis of pregnancy,ICP)与人类白细胞抗原-DQA1(human leucocyte antigen-DQA1,HLA-DQA1)等位基因多态性的关系。方法:采用聚合酶链反应-序列特异性引物(PCR-SSP)法研究遵义地区11例ICP孕妇和7例正常孕妇的HLA-DQA1基因的多态性。结果:所有标本共检出11种HLA-DQA1基因表型,ICP患者HLA-DQA1?0302基因频率高于正常孕妇(38.09%与14.28%),但二者差异无显著性(P>0.05)。结论:HLA-DQA1等位基因可能与遵义地区ICP的发病无明显关联性。
Objective： To investigate the relationship between human leucocyte antigen -DQA1 Polymorphism distribution in intrahepatic cholestasis of pregnancy. Methods： The HLA - DQA1 typing were analyzed using polymerase chain reaction with sequence - ape- cific primer （PCR -SSP） in I 1 patients and 7 healthy pregnant women. Results： The analysis showed no statistically significant difference between the two groups. Conclusion： It is unlikely that an HLA - DQA1 allele is primarily associated with susceptibility or resistance to ICP in Zunyi district.
出处
《中国妇幼保健》
CAS
北大核心
2008年第34期4904-4905,共2页
Maternal and Child Health Care of China
基金
遵义市红花岗区科学技术项目[项目编号:(2005)15-1]
关键词
妊娠期肝内胆汁瘀积症
人类白细胞抗原
等位基因
多态性
Intrahepatic cholestasis of pregnancy （ICP）
Human leucocyteantigen
HLA - DQA, alleles
Polymorphism
