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放射性^(99m)Tc标记的NMDA受体配基N_2S_2-Memantine的合成 被引量：4

Synthesis of NMDA receptor ^(99m)Tc labeling ligand of N_2S_2-Memantine
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摘要 以美金刚胺为原料,先与氯乙酰氯反应,再与二硫二氮缩合,最后与醋酸汞硫化氢反应脱巯基保护基得到标记前体N-[2-(N-(2-巯基乙基))氨基甲酰甲基]-N-(2-巯基乙基)-3,5-二甲基金刚烷胺基乙酰胺。关键化合物N-[2-((2-(S-(4-甲氧基苄基)巯基)乙基)氨基)乙酰基]-S-(4-甲氧基苄基)-2-氨基乙硫醇和N-[2-(S-(4-甲氧基苄基)硫基)乙基]-N-[(N-(2-(S-(4-甲氧基苄基)硫基)乙基)氨基)甲酰甲基]-3,5-二甲基金刚烷胺基乙酰胺得到核磁和质谱表征,总收率为32%。 The labeling precursor of N2S2-Memantine was synthesized from memantine via reaction with ehloroaeetyl chloride, followed by condensation with N2S2, and then deblocking proteeting group with Hg（OAc）2 and H2S.The structures of key compounds were confirmed by ^1HNMR, ^13CNMR and MS. The total product yield was 32 % .
作者 张建康 周杏琴 钦晓峰 邹美芬 徐希杰
机构地区 江苏省原子医学研究所
出处 《化学试剂》 CAS CSCD 北大核心 2008年第11期842-844,共3页 Chemical Reagents
基金 国家自然科学基金资助项目(30770602) 江苏省卫生厅重大项目(K200512)
关键词 NMDA受体 放射性配基 美金刚胺 双氨基乙硫醇类 ^99M锝标记 合成 NMDA receptor radioligand memanfine bis （aminoethanethiol） analog ^99mTc labeling synthesis
分类号 O625.72 [理学—有机化学] R981 [医药卫生—药品]
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参考文献13

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共引文献17

同被引文献59

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引证文献4

二级引证文献1

化学试剂
2008年 第11期

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