浊毒清治疗糖尿病周围神经病变40例临床观察

Effect of Zhuoduqing Decoction for the Treatment of Diabetic Peripheral Neuropathy:An Observation of 40 Cases

目的:观察浊毒清对糖尿病周围神经病变(DPN)的疗效。方法:将80例DPN患者随机分为2组,治疗组40例予浊毒清汤(组成:黄连、大黄、佩兰、草薢、黄芪、玄参、薏苡仁、三七、天冬、陈皮、法半夏、藿香、白豆蔻、山楂、苦杏仁)。口服;对照组40例予甲钴胺片500ug,口服,共治疗3月。结果:总有效率治疗组87.5%。对照组65.0%,2组临床疗效比较,差异有显著性意义(P<0.05);2组治疗前后血糖比较,差异无显著性意义(P>0.05)。2组治疗后积分明显下降,与治疗前比较,差异有非常显著性意义(P<0.01);2组治疗后比较,差异有非常显著性意义(P<0.01)。治疗后2组舌、脉象变化比较,差异有非常显著性意义(P<0.01),舌暗、苔腻、脉细、脉濡改善最为明显(P<0.01);2组治疗后运动传导速度、感觉传导速度均有下降,与治疗前比较,差异有显著性或非常显著性意义(P<0.05,P<0.01);2组治疗后运动传导速度、感觉传导速度比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:浊毒清治疗DPN有效,解毒化浊法是治疗DPN的有效方法之一。

Objective:To observe the therapeutic effect of Zhuoduqing group Decoction (ZD) for the treatment of diabetic peripheral neuropathy (DPN). Methods:Eighty DPN patients were equally randomized into 2 groups:the treatment group received oral use of ZD (mainly composed of Rhizoma Cop- tidis,Radix et Rhizoma Rhei, Herba Eupatorii,Rhizoma Dioecorese Hy- poglaneae,Radix Astragali,Radix Scrophularise,Semen Coicis,Radix Noto- ginseng,Radix Asparagi,Pericarpium Cirri Reticulatae,Rhizoma Pinelliae, Herba Agastaches,Fructus Amomi Rotundus,Fructus Crataegi,Semen Arme- niecse Amarum),and the control group received oral use of Mecobulamin Tablets 500μg.The treatment lasted 10 months.Results:The total effective rate was 87.5% in the treatment group and 65.0% in the control group,the difference being significant between the two groups (P<0.05).No significant difference was shown in blood glucose level in the two groups before and after treatment (P>0.05).The symptom score was decreased obviously after treat- merit in the two groups (P<0.01 compared with that before treatment),and the difference of symptom score was also significant between the two groups after treatment (P<0.01).The improvement of tongue and pulse manifestations was improved after treatment (P<0.01),in particular the dark tongue,greasy fur,thready pulse and soft pulse (P<0.01).The motion conduction speed and sensory conduction speed were decreased in the two groupe (P<0.05 or P<0.01 compared with those before treatment),and the decrease in the treat- meat group differed from those in the control group (P<0.05).Conclusion: ZD with the action of removing toxin and resolving turbidity is effective for the treatment of diabetic peripheral neuropathy.