急性有机磷杀虫药中毒患者肝、肾功能损害的研究

The study of nephritic and hepatic function injure in acute organophosphorous insecticides poisoning

目的研究急性有机磷杀虫药中毒(AOPP)患者的肝、肾功能各项检测指标水平变化的临床意义,以探讨AOPP患者肝、肾脏损伤的发病机制和防治对策。方法选择AOPP患者142例(A组),全部符合AOPP诊断标准,健康体检者100例为对照组(B组),检测各项数据。结果A组与B组比较:除血总蛋白(TP)、白蛋白(ALB)差异无统计学意义外(P>0.05),其余指标均有统计学意义。结论AOPP患者的肝、肾脏可有不同程度的损伤,而且随着中毒的加重而加重。

Objective To study the clinical significance of index of hepatic function, renal function in acute organophosphorus insecticides poisoning （AOPP）. And explore the pathogenesis and prevention and cure strategy of liver and kidney hurt. Methods 142 patients who were diagnosed acute organophosphorus toxieosis were selected as Group B, they were all matching the diagnostic standard of AOPP. They were suffering from the disease which had the same analysis index change were all precluded. Results Compared, All the results show statistical difference（P 〈 0. 01 or P 〈 0. 05） in group A and group B but TP and ALB （ P 〉 0. 05 ）. Conclusion The liver function and kidney function of the patients has been damaged, and the more severe the poisoning is, the more ponderosus they damage.