NF-κBp65在大肠癌中的表达及临床意义

Study on expression and clinical significance of NF-κBp65 in colorectal cancer

目的研究细胞核因子κB(NF-κB)p65在大肠癌中的表达及其与临床病理特征的关系,以探讨其在大肠癌发生、发展中的作用。方法采用免疫组化Elivision法检测60例大肠癌组织标本中NF-κBp65的表达情况。结果大肠癌组织中NF-κBp65阳性表达率为65%,癌旁正常组织阳性表达率为20%,两组比较差异有统计学意义(P<0.05)。NF-κBp65阳性表达与患者性别、年龄、病变部位、肿瘤大小无关;与病理分化程度、临床分期、淋巴结转移及浸润深度有关(P<0.05)。阳性表达者根治术后复发转移率与阴性表达者相比差异有统计学意义(P<0.05),并且阳性表达者生存率低于阴性者。结论NF-κBp65在大肠癌的发生、发展中起重要作用,可作为判断大肠癌侵袭转移及预后的预测指标。

Objective To study the expression of nuclear transcription factor - κBp65 （ NF - κBp65） in human colorectal cancer and its relationship to clinical pathologic feature. Methods The expression of eIF4E in 60 cases with colorectal cancer was examined by immunohistochemical assay. Results The positive rates of NF - κBp65 in the colorectal cancer tissues and the normal tissues of adjacent to cancer were 65% and 20%, respectively. Compared colorectal cancer tissue with the normal tissue of adjacent to cancer, there was a significance difference （P 〈 0.05 ）. The positive expression was associated with histological differentiation, invasiveness depth, lymph node metastasis and Dukes＂ stage, but no relation to patients＂ gender, age, profession, family history, location of cancer, tumor size. There were difference of recurrence and metastasis between patients with positive expression and negative ones who had radical resection. Conclusion NF - κBp65 may play an essential role in colorectal carcinogenesis and may be a good marker for predicting invasion, metastasis and prognosis of colorectal cancer.