胃肠癌术后腹腔温热灌注化疗联合体外高频透热治疗的疗效观察

THE EFFECTS OF INTRAPERITONEAL HYPERTHERMIC CHEMOTHERAPY COMBINING WITH HIGH-FREQUENCY DIATHERMIC THERAPY IN POSTOPERATIVE GASTROINTES-TINAL CANCER

目的:探讨胃肠癌术后病人行腹腔温热灌注化疗联合体外高频透热治疗的疗效。方法:我科收治的47例胃肠道恶性肿瘤术后病人,随机分为两组,一组为腹腔温热灌注化疗联合体外高频透热治疗组(治疗组),一组为单纯静脉化疗组(对照组)。结果:1.两组病人均随访2年,2年生存率有显著性差异(P<0.05),治疗组高于对照组,而1年生存率差异无显著意义(P>0.05)。2.两组不良反应分度及严重毒副反应比较无显著性差异。3.两组并发症的观察:治疗组较对照组腹胀的发生率略高,有统计学差异(P<0.05)。治疗组有4例出现腹痛,高于对照组的1例,但差异无显著性(P>0.05)。治疗组有2例术后出现肠梗阻、1例出现腹膜炎,两组术后无其他严重并发症。4.两组肝转移及腹腔淋巴结转移差异显著,治疗组明显低于对照组。结论:胃肠癌术后病人行腹腔温热灌注化疗联合体外高频透热治疗是一种并发症少、有效的治疗方法。

Objective：To explore the effect of intraperitoneal hyperthermie chemotherapy combing with high -frequency diathermic therapy （HFDT） in postoperative patients with gastrointestinal cancer. Methods：47 patients with gastrointestinal cancer after operation were randomly divided into two groups： one group of intraperitoneal hyperthermic chemotherapy combing with HFDT （treatment group） ,another group of intravenous chemotherapy alone （control group）. Results： 1. Two groups of patients were followed up for 2 years, 2 - year survival rates are significant differece （ P 〈 0. 05 ）, the survival rates of the treatment group were higher than the control group, and 1 - year survival rate has no significant difference（ P 〉 0. 05）. 2. Adverse reactions and serious toxicity has no significant difference between two groups＇ patients. 3. Complications incidence of abdominal distention in the treatment group is slightly higher than the control group,and has a significant difference（P 〈0. 05）. There are 4 cases of abdominal pain in the treatment group, and 1 case in the control group, but the difference was not significant（P 〉0. 05）. There are 2 cases of ileus and 1 case of peritonitis in the treatment group. There are no other serious complications in the two groups. 4. The liver metastasis and peritoneal metastasis in the two has a significant difference, the treatment group is significantly lower than the control group. Conclusion：Postoperative Gastrointestinal cancer patients are cured with intraperitoneal hgperthermic chemotherapy combining with HFDT, and this therapy is effective and few complications.