经支气管镜射频消融术治疗支气管肺癌临床价值的研究

The study on clinical values of bronchoscopic radiofrequency ablation therapy for bronchial carcinoma

目的探讨支气管镜下射频消融治疗支气管肺癌的疗效。方法选择2006年9月至2007年7月中南大学湘雅医院呼吸科42例经支气管镜检查并病理确诊的中央型支气管肺癌患者,X线胸片或CT证实有阻塞性肺炎或肺不张,在支气管镜下行射频消融治疗,以病变狭窄获得再通,临床症状改善的疗效进行评价。结果42例支气管肺癌经支气管镜下射频消融治疗3～4次后,临床评价完全有效11.9%(5/42)、部分有效50.0%(21/42)、轻度有效30.9%(13/42)、无效7.2%(3/42)。总有效率为92.8%。结论支气管镜下射频消融治疗能明显缩小肿瘤、通畅呼吸道,改善临床症状,消除肿瘤阻塞引起的肺炎、肺不张,是中央型支气管肺癌姑息治疗安全有效的手段之一。

Objective To evaluate the effects of bronchoscopic radiofrequency ablation therapy on bronchial carcinoma. Methods Totally 42 bronchial carcinoma patients were included in the study, who had got through bronchoseopie pathological diagnosis, with or without atelectasis or obstructive pneumonia on chest X-ray or chest CT. Radiofrequency ablation therapy was performed through bronchoseope. The location of the airway lesions, the degree of obstruction, dyspnea index and complications were all evaluated. Results Totally 42 patients with bronchial carcinoma were treated 3 - 4 times by bronehosepic radiofrequency ablation therapy. Full effectiveness was achieved in 5 cases （11.9%）, partial in 21 cases （50. 0% ） ,mild in 13 cases（30. 9% ） ,non-effectiveness in 3 cases（7.2% ）. The overall effective rate was 92. 8%. Conclusion Bronehoseopie radiofrequency ablation therapy on bronchial carcinoma can remarkably reduce the size of tumor, relieve clinical symptoms, and alleviated the obstruction caused by bronchial neoplasms. Thus, bronchoscopic radiofrequency ablation therapy is an effective and safe method of treatment for patients with bronchial carcinoma.