摘要
目的:观察恩丹西酮预防术后吗啡镇痛不良反应的临床效果。方法:将40例拟行子宫下段剖宫产术的健康产妇随机分为恩丹西酮组和对照组,每组20例。两组产妇均在关腹时硬膜外隙注射吗啡2mg镇痛,其中恩丹西酮组产妇分别在开腹和手术结束时静脉注射恩丹西酮4mg。术后24小时观察两组产妇的镇痛效果及恶心、呕吐、皮肤瘙痒等不良反应的发生情况。结果:两组产妇在24小时内镇痛效果均良好,VAS评分比较无显著性差异(P>0.05);恩丹西酮组产妇恶心、呕吐和皮肤瘙痒的发生率明显低于对照组(P<0.05,P<0.01)。结论:静脉注射恩丹西酮可在不改变镇痛效果的情况下,明显降低吗啡引起的恶心、呕吐和皮肤瘙痒等不良反应的发生。
Objective：To observe the clinical effects of ondansetron on adverse effects of Morphine analgesia after operation.Methods：40 low cesarean section lying-in women were randomly divided into 2 groups： ondansetron group and control group, each group had 20 women.The women in these 2 groups were all injected 2mg Morphine into the epidural space after operation;while the women in ondansetron group were intravenously injected 4mg ondansetron before and after operation respectively. The effects of analgesia and the occurrence of adverse effects induced by Morphine were observed 24h after operation.Results：The effects of analgesia were all well in 2 groups,and there had no obvious difference about the VAS score of ondansetron group and control group （P 〉 0.05）.In ondansetron group, the incidence of nausea,vomiting and itch of skin were obviously lower than that of control group （P 〈 0.05,P 〈 0.01）.Conclusions：Intravenous injection ondansetron can decrease the adverse effects induced by Morphine （such as nausea, vomiting and itch of skin） and does not affect the analgesia.
出处
《承德医学院学报》
2008年第4期363-365,共3页
Journal of Chengde Medical University
关键词
恩丹西酮
吗啡
不良反应
Ondansetron
Morphine
Adverse effect
