维甲酸受体α、β在子宫内膜癌组织中的表达及意义

Relation between the expression of RARα,RARβ and endometrial carcinoma

目的:通过检测子宫内膜癌组织中维甲酸受体α(Retinoic acid receptor α,RARα)及维甲酸受体β(Retinoic acidreceptor β,RARβ)表达情况,探讨维甲酸受体在子宫内膜癌发生发展及预后中的作用。方法:收集手术标本的石蜡切片48例,用免疫组化技术检测子宫内膜癌中RARα、RARβ的表达,评估其与临床病理参数之间的关系。结果:(1)RARα及RARβ的阳性表达率分别为47.92%(23/48)、25%(12/48),RARα的表达明显高于RARβ。(2)子宫内膜癌中RARα的表达随手术病理分期的增加及组织分化程度的降低而升高,表现出显著性差异(P<0.01,P<0.01),但与子宫内膜癌组织学分类、肌层侵润深度无关(P>0.05)。(3)RARβ的表达随着子宫内膜腺癌组织分化程度的降低而减少(P<0.05),但与手术病理分期、组织学类型、肌层侵润深度无关(P>0.05)。结论:子宫内膜癌中存在RARα、RARβ表达,RARα的高表达与子宫内膜癌的发展有关,RARβ的表达缺失及RARα的高表达预示子宫内膜癌的预后不良。

Objective：To evaluate the role of the retinoic acid receptor α（RARα）,retinoic acid receptor β（RARβ） in the development and prognosis of the endometrial carcinoma by detecting the expression of these receptors. Methods：48 cases of paraffin-embedded tissues were selected, including 42 cases of adenocarcinoma and 6 cases of adeno-squamous carcinoma of endometrium. Immunohistochemistry was used to detect the level of RARα and RARβ. The relation between the expression of these receptors and the clinical pathological parameters was evaluated. Results：The positive expression ratios of the RARα and RARβ were 47.92%（23/48）and 25.00%（12/48）,respectively. The level of RARα was significantly higher than that of RARβ（P〈0.05）. The expression of RARer in the endometrial carcinoma increased with the increase of the pathological stage and the decrease of the pathological differentiation, and the differences were significant（P〈0.01 ）. But the relation between the expression of these two receptors and the histological classifecation was nα significant, as well as the relation with the invasive depth in the muscle（P〉0.05）. The level of the RARβ decreased with the increasing of the malignancy extent of the endometrial adenocarcinoma（P〈0.05）,but there was no relationship between the level of the RARβ and the pathological stage, the histological classification, the invasive depth in the muscle（P〉0.05）respectively. Conclusion：There is close relation between the expression of the RARα and the development of the endometrial carcinoma. The defect of the RARβ and the high expression of the RARα indicates a bad prognosis of the endometrial carcinoma. Detection of these two is benefited receptors together for us to estimate the prognosis of the carcinoma.