摘要
[目的]研究桑白皮总黄酮(FCM)对组胺所致离体豚鼠气管收缩的影响。[方法]以离体豚鼠气管片为试验对象,观察桑白皮总黄酮对组胺引起收缩的影响。[结果]桑白皮总黄酮对豚鼠离体气管平滑肌的静息张力有舒张作用,-lgEC50为(3.96±0.65)g/ml;时效曲线显示FCM在60 min内拮抗浓度10-5mol/L组胺作用,-lgIC50为(3.81±0.23)g/m。l[结论]桑白皮总黄酮对组胺所致离体豚鼠气管收缩有抑制作用。
[ Objective ] The aim was to investigate the effects of the flavonoid of Cortex mori（FCM） on histamine （His） -induced tracheal contraction of guinea-pig in vitro. [ Method ] Guinea-pig tracheal smooth muscle was isolated and its contraction was induced by His. The antago- nistic effects of FCM were studied in vitro. [ Result] FCM relaxed the normal tone of isolated guinea-pig tracheal sheets, the - 1gEC50 （g/ml） for FCM was 3.96 ±0.65. FCM inhibited His-induced tracheal contraction of guinea-pig within 60 min. The-1gIC50 of FCM on contraction induced by 10^-5mol/L histamine was （3.81±0.23） g/ml. [ Conclusion] FCM could inhibit the histamine-induced tracheal contraction of guinea-pig in vitro.
出处
《安徽农业科学》
CAS
北大核心
2008年第32期14107-14107,14187,共2页
Journal of Anhui Agricultural Sciences
基金
广西工学院科学研究基金资助项目(院科硕05009)
关键词
桑白皮
黄酮
气管平滑肌
组胺
Cortex mori
Flavonoid
Tracheal smooth muscle
Histamine
