2型糖尿病肾病患者血清IL-18水平测定

Detection of interleukin-18 in type 2 diabetic patients with nephropathy

目的:观察2型糖尿病肾病(DN)患者血清IL-18水平变化。方法:酶联免疫吸附法(ELISA)测定90例DN患者(临床白蛋白、微量白蛋白及正常白蛋白尿各30例)和30例正常人血清IL-18含量,检测尿白蛋白排泄率(UAER)、血肌酐(SCr)、总胆固醇(TC)、甘油三酯(TG)、空腹血糖等指标。结果:DN患者血清IL-18水平较正常对照组升高,且随UAER的升高而逐渐升高(P<0.05)。DN患者IL-18水平与UAER、TC和TG呈正相关(r分别为0.418,0.019和0.032,P均<0.05),而与SCr、空腹血糖无关(r分别为0.468,0.361,P>0.05)。结论:IL-18可能参与了DN的形成与发展;IL-18有望成为判断DN肾损害程度的指标之一。

Aim： To investigate the changes of serum interleukin-18（IL-18） level in type 2 diabetic patients with nephropathy（DN）.Methods：Serum IL-18 in 90 DN patients and 30 health subjects was detected by ELISA,and urinary albumin excretion rate（UAER）,serum creatinine（SCr）,total cholesterol（TC）,triglyeride（TG） and fasting blood glucouse（FBG）were also deteched.Results： The serum IL-18 level in DN patients was significantly higher than that of the normal control,and increased with the UAER（P〈0.05）.The serum IL-18 in DN patients was positively related to the serum levels of UAER,TC and TG（r was 0.418,0.019 and 0.032,respectively,P〈0.05）,but not related to those of SCr and FBG（r was 0.468,0.361,respectively,P〉0.05）.Conclusion： IL-18 may play an important role during the development of DN,and it might be a predictor of severity of DN.