冠脉内置入药物涂层支架与金属裸支架对冠心病患者血浆C反应蛋白水平的影响

Effects of drug-eluting stent and bare metal stent on plasma C-reactive protein level in patient with coronary heart disease

目的:探讨冠脉内置入药物涂层支架(DES)和金属裸支架(BMS)对冠心病患者血浆C反应蛋白(CRP)水平的影响。方法:置入单个支架的稳定型心绞痛患者83例,其中成功置入DES 43例,成功置入BMS 40例,另选同期住院行冠脉造影检查显示冠状动脉不同程度狭窄而未行PCI的冠心病患者35例作对照,3组年龄、性别、身体状况、病变血管差异无统计学意义(P>0.05)。分别于术前和术后48、72 h和2周取静脉血2 mL,测定血浆CRP水平。结果:术前3组血浆CRP水平差异无统计学意义(P>0.05),术后48、72 h DES和BMS组血浆CRP水平均较对照组升高,但DES组升高幅度较小(P<0.05)。术后2周3组血浆CRP水平差异无统计学意义(P>0.05)。结论:DES可能不会引发PCI术后的急性炎症反应。

Aim：To explore the effects of drug-eluting stents（DES） and bare metal stent（BMS） implantation on plasma C-reactive protein（CRP） levels of coronary heart disease（CHD） patients.Methods：A total of 83 patients with CHD were performed by percutaneous coronary intervention（PCI） with a single stent implantation,and 43 patients were implanted DES and 40 with BMS.35 patients with coronary artery stenosis exceeding 70% but without PCI were the control group.Plasma CRP levels were measured before intervention and at 48,72 hours,2 weeks after coronary stenting.Results： There was no difference in clinical and angiographic baseline characteristics among the three groups（P〉0.05）.48,72 h after PCI,the plasma CRP levels in DES and BMS groups were significantly higher than those of the control group（P〈0.01）,moreover the CRP levels were significantly lower in the DES group than that in the BMS group（P〈0.01）.Two weeks after PCI,the plasma CRP levels in DES and BMS groups didn＇t differ from those of the control group（P〈0.01）,respectively.Conclusion： It indicated that DES couldn′t induce acute imflammation after PCI.