爱迪注射液配合化疗治疗晚期结肠癌疗效及免疫功能变化的观察

Observation on efficacy of aidi injection combined with chemotherapy in treating patients with colon carcinoma

目的比较爱迪注射液配合化疗(治疗组)与单纯化疗(对照组)对晚期结肠癌的疗效、生活质量及免疫功能的影响。方法62例晚期结肠癌患者随机分为爱迪注射液配合化疗组(治疗组)与单纯化疗组(对照组),连续治疗4周,并比较两组间疗效、生活质量及免疫功能。结果有效率治疗组43.7%,对照组33.3%,两组比较差异无显著性(P>0.05)。治疗组生活质量评分治疗组高于对照组,两组间差异有显著性(P<0.05)。治疗组治疗前后毒性反应、免疫功能改变明显低于对照组,差异有显著性(P<0.05)。结论爱迪注射液与化疗联用治疗晚期结肠癌,可降低化疗对患者免疫功能的影响及毒副反应,改善患者的生活质量。

Objective To investigate the therapeutic effect,adverse reaction and effect on immunity of chemotherapy combined Aidi injection with those of chemotherapy alone in treating patients with colon carcinoma. Methods 62 cases of colon carcinoma have been chosen and randomly divided into two groups：Aidi injection integration chemotherapy group （32cases） and only chemotherapy group （ 30 cases）. After four successive weeks of treatment, clinical effect, adverse reaction and the immune function were observed. Results The effective rate in the treated group and the control group was 43.7% and 33.3% respectively ,with insignificant difference between the two groups（P 〉 0. 05）. But the adverse reaction and change of immunity in the treated group were all lower than those in the control group with significance （ P 〈 0. 05 ）, and the improvement in Karnofsky scores in the former was higher than that in the latter （ P 〈 0. 05 ）. Conclusion Chemotherapy supplemented with Aidi injection shows apparent effect in treating patients with colon carcinoma, it could lower the influence on immunity and adverse reaction of chemotherapy, and improve the life quality of patients.