溶栓治疗时间窗对急性心肌梗死后血管再通的影响

Effect of Revascularization in the Time Window after Acute Myocardial Infarction Treated with Thrombolytic Therapy

目的探讨溶栓治疗时间窗对急性心肌梗死后血管再通的影响。方法回顾性分析37例AMI患者的溶栓疗效,根据发病后溶栓时间分为早期治疗组(0～6h)和延迟治疗组(6～12h)。结果早期治疗(0～6h)组血管再通率(79.17%)与延迟治疗(>6～12h)组的61.54%相比较,差异有统计学意义(P<0.05);两组5周病死率、反复心绞痛和反复Ⅱ度以上房室传导阻滞(AVB)相比,差异有统计学意义(P<0.01)。结论AMI发病后6h内溶栓治疗,血管再通效果最好,住院病死率最低,但发病时间>6～12h的溶栓治疗仍可取得较好的效果。

Objective To investigate the clinical value of revascularization in the different time after acute myocardial infarction （AMI）treated with thrombolytic therapy. Methods The 37 patients were divided into 2 groups according to thrombolytic time after AMI. Results The difference in the reopen rate of blood vessel between earlier therapy（0 - 6 h） and delayed therapy（ 〉 6 - 12 h） were significant （79. 17% ,61.54% ,P 〈 0.05 ） , the difference of mortality, repeating angina pectoris, Ⅱ degree atrioventrieular block during 5 weeks between these two groups were highly signifieant（P 〈0. 01 ）. Conclusion Thrombolytic therapy in 6 hours after AMI has better effect but delayed therapy（ 〉 6 - 12 h）still has moderate effect.