c-erbB原癌基因与银屑病

c erbB Proto oncogene and Psoriasis

为了探讨ｃ－ｅｒｂＢ与银屑病的关系，采用原位杂交的方法检测ｃ－ｅｒｂＢ－１原癌基因在正常人表皮和银屑病患者皮损表皮中的表达，并观察了正常人角朊细胞与银屑病患者ＩｇＧ和外周血单一核细胞作用后ｃ－ｅｒｂＢ－１的表达。结果表明：①ｃ－ｅｒｂＢ－１主要分布在正常人表皮基底细胞中，而在银屑病皮损中则全层表皮细胞均有表达，并以棘细胞层最为密集。②经银屑病患者ＩｇＧ和单一核细胞作用后的正常人角朊细胞内ｃ－ｅｒｂＢ－１表达的阳性颗粒数为０．５０３２±０．２３４３，与各对照组相比均明显增高（Ｐ均＜０．０１）。提示ｃ－ｅｒｂＢ－１的过度表达可能是导致银屑病角朊细胞异常增殖的重要原因之一。

In order to investigate the relationship between c erbB and psoriasis the expression of c erbB 1 proto oncogene in skins of normal controls and psoriatic lesions was examined by means of hybridization in situ, meanwhile, the expression of c erbB 1 in normal keratinocytes, which acted on psoriatic IgG and peripheral blood mononuclear cells, was carefully observed. The results showed: ①c erbB 1 proto oncogene was mainly localized in basal cells of normal epidermis, however, it was expressed throughout all layers of epidermis of psoriatic lesions, and was most intense in the prickle cell layer; ②grains of c erbB 1 expression were 0 5032±0 2343, which were increased obviously when compared with the control groups (P<0 01), when normal keratinocytes were stimulated with psoriatic IgG and mononuclear cells. Our results suggest that the overexpression of c erbB 1 proto oncogene might be one of the important reasons that can induce keratinocytes of psoriasis to proliferate abnormally.