灭活大肠埃希氏杆菌细菌培养液治疗溃疡性直肠炎的临床研究

Clinical study of inactivated escherichia coli bacterial culture suspensionin treatment of ulcerative proctitis

目的观察灭活大肠埃希氏杆菌细菌培养液治疗溃疡性直肠炎的临床疗效和安全性。方法选择150例符合轻、中度溃疡性直肠炎诊断的患者随机分灭活埃希的松软膏组、SASP栓组和1%醋酸氢化可的松软膏组,疗程均为4周。对三组患者治疗前后的症状和肛门镜检查及不良反应进行比较。结果试验组症状改善有效率高于SASP栓组和1%醋酸氢化可的松软膏组(60%、48%、22%,P<0.01)。试验组肛门镜检查改善有效率高于SASP栓对照组和1%醋酸氢化可的松软膏对照组(64%、50%、20%,P<0.01)三组不良反应发生率为0。结论灭活大肠埃希氏杆菌细菌培养液治疗轻、中度溃疡性直肠炎安全有效。

Objective To evaluate the effect and safety of inactivated escherichia coli bacterial culture suspension in the treatment of ulcerative procitis. Methods One hundred and fifty patients with mild-moderate ulcerative proetitis were divided randomly into inactivated eseheriehia eoli and hydroeortisone ointment group （ n = 50）, sulfasalazine suppository group （ n = 50 ） and 1% hydroeortisone ointment group （ n = 50 ）, with a course of treatment for four weeks. The efficacy and adverse reactions of this drug were evaluated on the basis of the clinical improvements shown by symptoms and anoseopy changes. Results The rate of symptoms changes total efficiency in inactivated escherichia coli and hydrocortisone ointment group was higher than that in sulfasalazine suppository group and 1% hydrocortisone ointment group （60% ,48%, 22%, P 〈 0. 05 ）. The rate of anoscopy changes total efficiency in inactivated escherichia coli and hydrocortisonc ointment group was higher than that in sulfasalazine suppository group and 1% hydrocortisone ointment group （64%, 50%, 20%, P 〈 0. 05 ）. The rate of drub adverse reaction in three groups were 0. Conclusion Inactivated escherichia coli bacterial culture suspension is obviously effective and safe in the treatment of mild-moderate ulcerative proctitis.